KCC2 is a potassium (K +)/chloride (Cl −) symporter that maintains chloride homeostasis in neurons. The electrochemical chloride gradient established by KCC2 activity is crucial for classical postsynaptic inhibition through GABA A receptors and glycine receptors in the central nervous

2023年9月13日 · Strategies focusing on direct (enhancing KCC2 activation) and indirect KCC2 modulation (altering KCC2 phosphorylation and transcription) have proven effective in attenuating seizure severity...

2019年10月25日 · 钾-氯共转运蛋白KCC利用这个钾离子浓度梯度，将细胞内的钾离子和氯离子一起转运至细胞外，从而调控细胞内的氯离子浓度。 氯离子浓度是一个很关键的指标。 例如，在γ-氨基丁酸介导的抑制性神经传递过程中，抑制性神经元需要维持细胞内较低的氯离子浓度才能发挥正常的抑制作用。...

钾氯共转运体-2（KCC2）是阳离子和氯离子共转运体家族中的一员，广泛分布于中枢神经系统（CNS），主要负责把细胞内的氯离子泵出细胞外，维持抑制性神经元的抑制功能所必需的低氯环境。 KCC2的下调参与一些神经系统疾病和疼痛的发生和发展，而KCC2本身亦受多种因素的调节。 该文就KCC2的调节机制作一综述。 关键词: 钾氯共转运体-2, 调节, 疼痛. Abstract:...

2017年11月28日 · KCC2 is a neuron specific K + -Cl − co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism...

KCC2 is a secondary active transporter, i.e., it uses the energy of the electrochemical K + gradient to transport Cl −. The electrochemical plasma membrane K + gradient is generated by the primary active transporter Na-K ATPase (Figure 3). KCC2 colocalizes and structurally interacts with the α2 subunit of the Na-K ATPase (Ikeda et al., 2004 ...

2024年12月10日 · KCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition within the CNS. Herein, we highlight KCC2 hypofunction as a fundamental and conserved pathology contributing to neuronal circuit …

2021年2月24日 · KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD).

The neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as an active Cl− extrusion pathway important in postsynaptic inhibition mediated by ligand-gated anion channels, like γ-aminobutyric acid type A (GABAA) and glycine receptors.

2017年11月28日 · KCC2 is a neuron specific K + -Cl - co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia.