Chloride potassium symporter 5 - Wikipedia
KCC2 is a potassium (K +)/chloride (Cl −) symporter that maintains chloride homeostasis in neurons. The electrochemical chloride gradient established by KCC2 activity is crucial for …
Neuronal K+-Cl- cotransporter KCC2 as a promising drug target …
2023年9月13日 · Strategies focusing on direct (enhancing KCC2 activation) and indirect KCC2 modulation (altering KCC2 phosphorylation and transcription) have proven effective in …
浙大研究刊登《科学》：“看清”钾-氯共转运蛋白的结构，为治疗癫 …
2019年10月25日 · 钾-氯共转运蛋白KCC利用这个钾离子浓度梯度，将细胞内的钾离子和氯离子一起转运至细胞外，从而调控细胞内的氯离子浓度。 氯离子浓度是一个很关键的指标。 例如， …
钾氯共转运体-2调节机制的研究进展 - shsmu.edu.cn
钾氯共转运体-2（KCC2）是阳离子和氯离子共转运体家族中的一员，广泛分布于中枢神经系统（CNS），主要负责把细胞内的氯离子泵出细胞外，维持抑制性神经元的抑制功能所必需的低 …
Molecular architecture of potassium chloride co-transporter KCC2
2017年11月28日 · KCC2 is a neuron specific K + -Cl − co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain …
Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and ...
KCC2 is a secondary active transporter, i.e., it uses the energy of the electrochemical K + gradient to transport Cl −. The electrochemical plasma membrane K + gradient is generated …
Development of KCC2 therapeutics to treat neurological disorders
2024年12月10日 · KCC2 is CNS neuron-specific chloride extruder, essential for the establishment and maintenance of the transmembrane chloride gradient, thereby enabling synaptic inhibition …
The Multifaceted Roles of KCC2 in Cortical Development - Cell Press
2021年2月24日 · KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional …
The Neuron-specific K-Cl Cotransporter, KCC2 - Journal of …
The neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as an active Cl− extrusion pathway important in postsynaptic inhibition mediated by ligand-gated anion …
Molecular architecture of potassium chloride co-transporter KCC2
2017年11月28日 · KCC2 is a neuron specific K + -Cl - co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain …