Frontiers | PIP2 regulation of KCNQ channels: biophysical and …
Recent studies suggest that PIP 2 serves as a cofactor to mediate VSD-PGD coupling in KCNQ1 channels. In this review, we put these findings in the context of the current understanding of …
Cholinergic control of ventral surface chemoreceptors involves Gq ...
Voltage‐gated KCNQ channels have a high propensity for modulation by Gq‐signalling (Jentsch, 2000). In particular, activation of M1 or M3 receptors has been shown to inhibit KCNQ channel …
Regulation of KCNQ2/KCNQ3 Current by G Protein Cycling
2004年1月27日 · Receptor-mediated modulation of KCNQ channels regulates neuronal excitability. This study concerns the kinetics and mechanism of M 1 muscarinic …
Functional effects of KCNQ K (+) channels in airway smooth …
2013年10月7日 · KCNQ (Kv7) channels underlie a voltage-gated K (+) current best known for control of neuronal excitability, and its inhibition by Gq/11-coupled, muscarinic signaling. …
Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 …
2019年2月2日 · KCNQ (Kv7, “M-type”) K + channels and TRPC (transient receptor potential, “canonical”) cation channels are coupled to neuronal discharge properties and are regulated …
光遗传学&化学遗传学，调控特定神经元活性——21世纪神经科学 …
该技术利用分子生物学、病毒生物学等手段，将外源光敏感蛋白基因导入活细胞中，在细胞膜结构上表达了光敏感通道蛋白；然后通过特定波长光的照射，控制细胞膜结构上的光敏感通道蛋白 …
Neural KCNQ (Kv7) channels - PubMed
KCNQ genes encode five Kv7 K (+) channel subunits (Kv7.1-Kv7.5). Four of these (Kv7.2-Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular …
Ligand activation mechanisms of human KCNQ2 channel - Nature
2023年10月19日 · Here we report cryo-electron microscopy (cryo-EM) structures of human KCNQ2-CaM in complex with three activators, namely the antiepileptic drug cannabidiol …
(PDF) Regulation of KCNQ2/KCNQ3 Current by G Protein Cycling …
2004年7月1日 · Receptor-mediated modulation of KCNQ channels regulates neuronal excitability. This study concerns the kinetics and mechanism of M1 muscarinic receptor-mediated …
Voltage-gated potassium channels KCNQs: Structures, …
2023年12月31日 · In this review, we summarize the currently available structures of KCNQ channels, analyze their special voltage gating mechanism, and discuss their activation …