Frontiers | KCNQs: Ligand- and Voltage-Gated Potassium Channels
2020年6月22日 · Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms …
KCNQs: Ligand- and Voltage-Gated Potassium Channels
2020年6月23日 · Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms …
Neural KCNQ (Kv7) channels - PubMed
KCNQ genes encode five Kv7 K (+) channel subunits (Kv7.1-Kv7.5). Four of these (Kv7.2-Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular …
Voltage-gated potassium channels KCNQs: Structures, …
2023年12月31日 · KCNQ (Kv7) channels are voltage-gated, phosphatidylinositol 4,5-bisphosphate- (PIP 2 -) modulated potassium channels that play essential roles in regulating …
靶向KCNQ的蝎多肽药物设计与研究进展 - 知乎专栏
摘要： 电压门控钾离子通道 Kv7.1-Kv7.5 (KCNQ1-5)分布于心脏 (KCNQ1)、中枢和外周神经元 (KCNQ2-KCNQ5)，对膜兴奋性有强烈的抑制作用，其功能异常是心脏 长QT综合征 (long QT …
Direct neurotransmitter activation of voltage-gated potassium ... - Nature
2018年5月10日 · Voltage-gated potassium channels KCNQ2–5 generate the M-current, which controls neuronal excitability. KCNQ2–5 subunits each harbor a high-affinity anticonvulsant …
Neuronal KCNQ potassium channels:physislogy and role in disease
2000年10月1日 · Mark Keating and colleagues 3 identified KvLQT1 (now called KCNQ1) as one of the ion channels underlying the long-QT syndrome ( LQTS), a potentially fatal inherited …
A small-molecule activation mechanism that directly opens the …
2024年1月2日 · Through structure-based virtual screening, we identified a new scaffold compound, Ebio1, serving as a potent and subtype-selective activator for the voltage-gated …
iHuman研究所徐菲课题组与合作者揭示电压门控钾通道受脂类分子调控的新机制
2021年11月12日 · 电压门控钾通道（Voltage-gated potassium channel，Kv）促进钾离子在动作电位复极化阶段流出细胞，从而调节神经元和心肌等可兴奋细胞的膜电位，对神经系统和心脏等 …
KCNQ钾通道及其小分子调节剂研究进展 - 道客巴巴
2016年12月29日 · KCNQ 钾通道包括 KCNQ1~KCNQ5 五个亚型，在心脏、神经元和平滑肌等组织广泛分布，并在调节细胞兴奋性和离子平衡中发挥着重要的生理功能。 KCNQ 功能失调导 …