KLB基因 编码蛋白β-klotho，是内分泌 成纤维细胞生长因子 21(FGF21)受体复合物主要部分，两者结合后，刺激 胰岛素敏感性 ，引起体重下降。 FGF21由肝脏产生，作用于脂肪和胰腺组织，能通过 血脑屏障 ，在调控能量代谢中发挥关键作用。

However, the regional and cellular target(s) for FGF21 to suppress alcohol consumption are unknown. To identify central FGF21 target regions, we labeled KLB-expressing cells with the fluorescent protein tdTomato through viral delivery of a PHP.eB-FLEX-tdTomato virus (Chan et al., 2017) to KLB-Cre mice (Jensen-Cody et al., 2020) (Figure 2A).

2020年8月4日 · Our work provides important new insights into how the liver-derived hormone FGF21 signals to the CNS to regulate macronutrient intake. Using knock-in reporter (i.e., Klb-CRE) mice, we find that KLB is expressed in many regions of the hypothalamus.

2022年8月23日 · Using a mouse model that drives CRE recombinase in FGF21-expressing cells, we demonstrate that FGF21 is not expressed in the hypothalamus, but instead is produced from the retrosplenial cortex (RSC), an essential brain region for spatial learning and memory.

这个等位基因是通过同源重组，在b-kllotho（基因名：Klb）的第1外显子插入，包含CRE重组酶和tdTomato报告基因序列的构建，两者由一个间隔的IRES序列分隔的（来源：J:296603）。

Download Form 2 CRE Notes for free at no cost. These CRE notes follows the Kenya Certificate of Secondary Education CRE Form 2 syllabus. Our notes have been prepared by qualified professional teachers. Download these free notes in pdf/word formats and use them in your CRE class during teaching and/or revision.

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