Krueppel-like factor 1 is a protein that in humans is encoded by the KLF1 gene. The gene for KLF1 is on the human chromosome 19 and on mouse chromosome 8. Krueppel-like factor 1 is a transcription factor that is necessary for the proper maturation of erythroid (red blood) cells.

2024年12月25日 · KLF1 (KLF Transcription Factor 1) is a Protein Coding gene. Diseases associated with KLF1 include Anemia, Congenital Dyserythropoietic, Type Iva and Fetal Hemoglobin Quantitative Trait Locus 6.

klf1可在红系-巨核系祖细胞及红系各阶段细胞中表达，通过与其他谱系特异性转录因子之间的相互作用，调控红系谱系分化。对人和小鼠造血祖细胞谱系分化的研究发现，klf1与gata1的转录水平呈正相关关系，二者在红系谱系的建立中发挥协同驱动作用 。

Erythroid KLF (EKLF or KLF1) was the first family member to be identified in mice and humans (49) and is a master regulator of definitive erythropoiesis. It is expressed specifically in erythroid cells and positively regulates the adult β-globin gene (20, 49).

2025年2月8日 · KLF1 and KLF2 positively regulate the embryonic and fetal beta-globin genes through direct promoter binding. Six different KLF1 mutations were identified in 52 of 145 subjects with borderline HBA2 and normal mean corpuscular volume and mean corpuscular hemoglobin.

2024年2月15日 · Klf1 is involved in erythrocyte development and regulating the developmental transition from fetal hemoglobin to adult hemoglobin by arranging the expression of numerous genes, including BCL11A. A Klf1 mutation may have consequences that lessen the effects of beta thalassemia ( Fanis et al., 2019 ).

KLF1是一个基本的红细胞系特异性转录因子，由Miller和Bieker 在1993年首次确认。KLF1 C端高度保守，包含3个串联的C2H2锌指序列组成的DNA结合结构域，N端是富含脯氨酸的转录活化区。KLF1可识别多个位于红细胞相关基因的启动子或增强子CACCC序列。

2025年2月8日 · KLF1 directly regulates most aspects of terminal erythroid differentiation including alpha-, beta-globin, and heme biosynthesis, coordination of proliferation and anti-apoptotic pathways, and construction of the red cell membrane and cytoskeleton.

2024年4月11日 · Clinical resource with information about KLF1, BLOOD GROUP--LUTHERAN INHIBITOR, Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles., Congenital dyserythropoietic anemia type 4, Fetal hemoglobin quantitative trait locus 6, and available tests.

Erythroid Krüppel-like factor (EKLF or KLF1) is a transcriptional regulator that plays a critical role in lineage-restricted control of gene expression. KLF1 expression and activity are tightly controlled in a temporal and differentiation stage-specific manner.