2020年12月7日 · KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by poly …

2020年10月1日 · Here we show that the KLF4, involved in cellular homeostasis, proliferation, cell reprogramming and cancer development, directly regulates resection and homologous …

2012年1月27日 · We provide mechanistic insights into KLF4 degradation and show that pVHL depletion in colorectal cancer cells leads to cell-cycle arrest concomitant with increased …

2017年5月29日 · We show that KLF4 promotes cell adhesion, migration, and morphological changes, all of which are abolished by R458A mutation. Surprisingly, 116 genes are directly …

2022年2月17日 · High expression of KLF4 was associated with good prognosis in BC (HR OS = 0.49, 95% CI: 0.33–0.72) and head and neck tumours (HR OS = 0.41, 95% CI: 0.23–0.75), …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and …

2020年11月24日 · genome stability through regulating KLF4 transcriptional function by dictating its recruitment to the chromatin, ensuring DNA damage response. We further unveiled a newly …

2021年8月14日 · We found that KLF4 is critically implicated in M2 polarization of macrophages, which, in turn, promotes tumorigenesis. KLF4 expression correlated with miR-34a-5p and IL …

2018年10月1日 · We conducted a meta-analysis to evaluate the prognostic value of KLF4 in tumors. Low KLF4 expression was associated with worse OS and DFS of various solid tumors. …

2009年11月20日 · KLF4 是 Kruppel 样因子家族的另一个成员，可以激活和抑制参与多种细胞过程的基因。 我们最近报道，KLF4 是一种新型抑制途径的一部分，该途径可防止稳态期间幼稚 T …