
New insight into the significance of KLF4 PARylation in genome ...
2020年12月7日 · KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by poly …
Methylation of the central transcriptional regulator KLF4 by …
2020年10月1日 · Here we show that the KLF4, involved in cellular homeostasis, proliferation, cell reprogramming and cancer development, directly regulates resection and homologous …
Regulation of KLF4 Turnover Reveals an Unexpected
2012年1月27日 · We provide mechanistic insights into KLF4 degradation and show that pVHL depletion in colorectal cancer cells leads to cell-cycle arrest concomitant with increased …
Methylated cis -regulatory elements mediate KLF4-dependent …
2017年5月29日 · We show that KLF4 promotes cell adhesion, migration, and morphological changes, all of which are abolished by R458A mutation. Surprisingly, 116 genes are directly …
Prognostic significance of KLF4 in solid tumours: an updated meta ...
2022年2月17日 · High expression of KLF4 was associated with good prognosis in BC (HR OS = 0.49, 95% CI: 0.33–0.72) and head and neck tumours (HR OS = 0.41, 95% CI: 0.23–0.75), …
Krüppel-like factor 4 (KLF4): What we currently know - PMC
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and …
2020年11月24日 · genome stability through regulating KLF4 transcriptional function by dictating its recruitment to the chromatin, ensuring DNA damage response. We further unveiled a newly …
Comprehensive Integrative Analysis Reveals the Association of KLF4 …
2021年8月14日 · We found that KLF4 is critically implicated in M2 polarization of macrophages, which, in turn, promotes tumorigenesis. KLF4 expression correlated with miR-34a-5p and IL …
Krüppel-like factor 4 expression in solid tumor prognosis: A meta ...
2018年10月1日 · We conducted a meta-analysis to evaluate the prognostic value of KLF4 in tumors. Low KLF4 expression was associated with worse OS and DFS of various solid tumors. …
Krüppel 样因子 4 (KLF4) 调节自然杀伤细胞的存活和组织分布 …
2009年11月20日 · KLF4 是 Kruppel 样因子家族的另一个成员,可以激活和抑制参与多种细胞过程的基因。 我们最近报道,KLF4 是一种新型抑制途径的一部分,该途径可防止稳态期间幼稚 T …