2020年12月7日 · KLF4 plays a critical role in determining cell fate responding to various stresses or oncogenic signaling. Here, we demonstrated that KLF4 is tightly regulated by poly (ADP‐ribosyl)ation (PARylation). We revealed the subcellular compartmentation for KLF4 is orchestrated by PARP1‐mediated PARylation.

2020年10月1日 · Here we show that the KLF4, involved in cellular homeostasis, proliferation, cell reprogramming and cancer development, directly regulates resection and homologous recombination proficiency. Indeed, resection efficiency follows KLF4 protein levels, i.e. decreases upon KLF4 downregulation and increases when is overexpressed.

2012年1月27日 · We provide mechanistic insights into KLF4 degradation and show that pVHL depletion in colorectal cancer cells leads to cell-cycle arrest concomitant with increased transcription of the KLF4-dependent p21 gene. Finally, immunohistochemical staining revealed elevated pVHL and reduced KLF4 levels in colon cancer tissues.

2017年5月29日 · We show that KLF4 promotes cell adhesion, migration, and morphological changes, all of which are abolished by R458A mutation. Surprisingly, 116 genes are directly activated via mCpG-dependent KLF4 binding activity.

2022年2月17日 · High expression of KLF4 was associated with good prognosis in BC (HR OS = 0.49, 95% CI: 0.33–0.72) and head and neck tumours (HR OS = 0.41, 95% CI: 0.23–0.75), which is different from previous results.

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and differentiation. Since its discovery in 1996, KLF4 has been ...

2020年11月24日 · genome stability through regulating KLF4 transcriptional function by dictating its recruitment to the chromatin, ensuring DNA damage response. We further unveiled a newly discovered function of KLF4 in modulating HR through regulating BRCA1 in a PARylation-independent manner. Finding a functional interaction between KLF4 and PARP1 in

2021年8月14日 · We found that KLF4 is critically implicated in M2 polarization of macrophages, which, in turn, promotes tumorigenesis. KLF4 expression correlated with miR-34a-5p and IL-1β in a feed-forward loop (FFL), both of which are implicated in immune regulation.

2018年10月1日 · We conducted a meta-analysis to evaluate the prognostic value of KLF4 in tumors. Low KLF4 expression was associated with worse OS and DFS of various solid tumors. KLF4 might be a potential biomarker and therapeutic target for human solid tumors.

2009年11月20日 · KLF4 是 Kruppel 样因子家族的另一个成员，可以激活和抑制参与多种细胞过程的基因。 我们最近报道，KLF4 是一种新型抑制途径的一部分，该途径可防止稳态期间幼稚 T 细胞的增殖并保留淋巴结中的记忆 T 细胞（Yamada 等，Nature Immunology，2009）。