
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
2015年5月22日 · Histone–lysineN-methyltransferase 2 (KMT2) family proteins, initially named the mixed lineage leukaemia (MLL) family, are altered in many types of cancers beyond MLL.
KMT2D - Wikipedia
Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono- methyltransferase. [5] .
KMT2A - Wikipedia
KMT2A gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains.
KMT2D Gene - GeneCards | KMT2D Protein | KMT2D Antibody
2024年12月25日 · KMT2D (Lysine Methyltransferase 2D) is a Protein Coding gene. Diseases associated with KMT2D include Kabuki Syndrome 1 and Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).
Histone–lysine N-methyltransferase 2 (KMT2) complexes – a new ...
2022年7月1日 · The Histone–Lysine N-Methyltransferase 2 (KMT2) protein family catalyzes histone H3 Lys4 (H3K4) methylation, and its members are needed for gene expression control. Using their Suppressor of variegation 3–9, Enhancer of Zeste, Trithorax (SET) domain, they catalyze the mono-, di-, or trimethylation of histone 3 at Lys4 (H3K4) on the chromatin.
Mutation status of the KMT2 family associated with immune …
2024年1月15日 · The histone-lysine N-methyltransferase 2 (KMT2) family plays a crucial role in the methylation of histone H3 at lysine 4. By influencing chromatin structure and DNA accessibility, this modification serves as a key regulator of tumor progression and immune tolerance across various tumors.
KMT2D gene: MedlinePlus Genetics
The KMT2D gene, also known as MLL2, provides instructions for making an enzyme called lysine-specific methyltransferase 2D that is found in many organs and tissues of the body. Lysine-specific methyltransferase 2D functions as a histone methyltransferase. Histone methyltransferases are enzymes that modify proteins called histones.
KMT 2 - Lock nuts and locking devices | SKF - SKF USA
KMT precision lock nuts are intended for applications where high precision, simple assembly and reliable locking are required. The three equally-spaced locking pins enable these lock nuts to be accurately positioned at right angles to the shaft.
中国国民党 - 百度百科
中国国民党(Kuomintang of China,缩写KMT;亦可直译作“Chinese Nationalist Party”),由孙中山先生创立,其前身是兴中会、中国同盟会、国民党、中华革命党。
KMT2A- rearranged leukemia: the shapeshifter - American Society …
2022年10月27日 · Models of the cell of origin of lineage-switched relapse in infant KMT2A-r leukemia. Tirtakusuma et al. identified 3 different scenarios: (1) relapsed AML cells lack BCR rearrangement; (2) both ALL and AML cells present BCR rearrangements but they are different; and (3) ALL and AML cells share the same BCR rearrangement.