2015年5月22日 · Histone–lysineN-methyltransferase 2 (KMT2) family proteins, initially named the mixed lineage leukaemia (MLL) family, are altered in many types of cancers beyond MLL.

Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono- methyltransferase. [5] .

KMT2A gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains.

2024年12月25日 · KMT2D (Lysine Methyltransferase 2D) is a Protein Coding gene. Diseases associated with KMT2D include Kabuki Syndrome 1 and Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).

2022年7月1日 · The Histone–Lysine N-Methyltransferase 2 (KMT2) protein family catalyzes histone H3 Lys4 (H3K4) methylation, and its members are needed for gene expression control. Using their Suppressor of variegation 3–9, Enhancer of Zeste, Trithorax (SET) domain, they catalyze the mono-, di-, or trimethylation of histone 3 at Lys4 (H3K4) on the chromatin.

2024年1月15日 · The histone-lysine N-methyltransferase 2 (KMT2) family plays a crucial role in the methylation of histone H3 at lysine 4. By influencing chromatin structure and DNA accessibility, this modification serves as a key regulator of tumor progression and immune tolerance across various tumors.

The KMT2D gene, also known as MLL2, provides instructions for making an enzyme called lysine-specific methyltransferase 2D that is found in many organs and tissues of the body. Lysine-specific methyltransferase 2D functions as a histone methyltransferase. Histone methyltransferases are enzymes that modify proteins called histones.

KMT precision lock nuts are intended for applications where high precision, simple assembly and reliable locking are required. The three equally-spaced locking pins enable these lock nuts to be accurately positioned at right angles to the shaft.

中国国民党（Kuomintang of China，缩写KMT；亦可直译作“Chinese Nationalist Party”），由孙中山先生创立，其前身是兴中会、中国同盟会、国民党、中华革命党。

2022年10月27日 · Models of the cell of origin of lineage-switched relapse in infant KMT2A-r leukemia. Tirtakusuma et al. identified 3 different scenarios: (1) relapsed AML cells lack BCR rearrangement; (2) both ALL and AML cells present BCR rearrangements but they are different; and (3) ALL and AML cells share the same BCR rearrangement.