KDM4C Gene - GeneCards | KDM4C Protein | KDM4C Antibody
2024年12月25日 · KDM4C (Lysine Demethylase 4C) is a Protein Coding gene. Diseases associated with KDM4C include Hematologic Cancer and Squamous Cell Carcinoma. Among …
KDM4C - Wikipedia
Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene. [5][6][7] This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein …
赖氨酸脱甲基酶 4C（KDM4C）基因 | MCE - MCE-生物活性 ...
编码的蛋白质是一种三甲基化特异性去甲基化酶，可将特定的三甲基化组蛋白残基转化为二甲基化形式。 这种酶促作用调节基因表达和染色体分离。 在肿瘤细胞中可能会发现染色体畸变和该 …
Cell Death Differ：KDM4C通过表观遗传学修饰促进肺癌放疗抗性 …
2021年2月9日 · KDM4C（组蛋白赖氨酸脱甲基酶4C，也称为JMJD2C/GASC1）是JmjC蛋白家族的成员之一，其编码与H3K9me3/2和H3K36me3/2相关的组蛋白去甲基化酶，且已证实该基因 …
Histone demethylase KDM4C controls tumorigenesis of …
2021年1月18日 · KDM4C is a histone H3K9 demethylase that contributes to epigenetic regulation of both oncogene and tumor suppressor genes and is often overexpressed in human...
USP9X-mediated KDM4C deubiquitination promotes lung …
2021年2月8日 · Here, we show that lysine-specific demethylase 4C (KDM4C) is overexpressed and correlated with poor prognosis in lung cancer patients. We provide evidence that genetical …
KDM4C silencing inhibits cell migration and enhances ... - Nature
2023年4月28日 · Here, we find that KDM4C protein expression is increased in HCC and promotes HCC cell growth, proliferation and migration. Furthermore, we provide evidence that depletion …
Targeting KDM4C enhances CD8+ T cell mediated antitumor
Mechanistically, KDM4C inhibition increased the binding of H3K36me3 to the CXCL10 promoter region, thus inducing CXCL10 transcription and enhancing the CD8 + T cell mediated …
KDM4C, a H3K9me3 Histone Demethylase, is Involved in
2016年10月1日 · KDM4C, also known as JMJD2C/GASC1, is a member of the KDM4 subgroup of JmjC domain-containing proteins which catalyzes the demethylation of tri- and dimethylated …
KDM4C lysine demethylase 4C [ Homo sapiens (human) ]
Title: KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations. The histone demethylase JMJD2C constitutes a novel NFE2 target …