2024年12月25日 · KDM5B (Lysine Demethylase 5B) is a Protein Coding gene. Diseases associated with KDM5B include Intellectual Developmental Disorder, Autosomal Recessive 65 and Autism Spectrum Disorder. Among its related pathways are Gene expression (Transcription) and RNA Polymerase I Promoter Opening.

2021年10月20日 · KDM5B recruits SETDB1 to repress endogenous retroelements such as MMVL30, suppressing anti-tumour immunity, and the depletion of KDM5B induces a robust adaptive immune response and enhances the...

kdm5b是一种组蛋白去甲基化酶，是kdm5 4种亚型中的一种，参与表观遗传调控过程，与肿瘤等疾病有密切关系。上述结果表明kdm5b可能是icb响应低的生物标志物，靶向kdm5b可能诱导t细胞浸润并克服对icb的耐药性，这引起了研究人员极大的兴趣。

The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development.

2022年12月12日 · In this review, we adopt a unique perspective regarding the context-dependent roles of KDM5A and KDM5B in development and tumorigenesis. It is well known that these two proteins show a high...

赖氨酸脱甲基酶5b（kdm5b）是2007年鉴定出的组蛋白脱甲基酶，负责清除h3k4me2 / 3激活标记。它参与靶基因启动子周围的多种阻遏性转录复合物，并对染色质结构执行广泛的调节作用。到目前为止，越来越多的证据表明kdm5b具有致癌作用。

2025年3月10日 · KDM5B is a well-known histone demethylase and master regulator of histone modifications that functions as a key mediator of chromatin organization, transcriptional control, and genome stability ...

2025年2月8日 · KDM5B, a histone demethylase known to be involved in breast cancer tumorigenesis, as a target of miR-137. Data show that KDM5B is frequently up-regulated in hepatocellular carcinoma tissues and cell lines and correlated with poor prognosis. Its depletion leads to highly impaired clonogenesis and cell cycle arrest through up-regulation of p15 ...

赖氨酸脱甲基酶 5B： 该基因编码赖氨酸特异性组蛋白去甲基化酶，属于包含 jumonji/ARID 结构域的组蛋白去甲基化酶家族。 编码的蛋白质能够使组蛋白 H3 的三甲基化、二甲基化和单甲基化赖氨酸 4 去甲基化。 该蛋白在转录抑制或某些肿瘤抑制基因中发挥作用，并在某些癌细胞中上调。 这种蛋白质也可能在基因组稳定性和 DNA 修复中发挥作用。 交替剪接导致多个转录本变体。 [RefSeq 提供，2016 年 11 月]

2020年12月15日 · KDM5B (Lysine-Specific Demethylase 5B) erases the methyl group from H3K4me2/3, which performs wide regulatory effects on chromatin structure, and represses the transcriptional function of genes. KDM5B functions as an oncogene and associates with human cancers closely.