2025年2月17日 · Comprehensive clinicopathological analysis of 112 cases of Kikuchi-Fujimoto disease (KFD) was conducted, and offered insights into recurrence risk factors and histopathological patterns. Recurrent KFD may fall between transient KFD and overt autoimmune disorders and lead to a better understanding of the aetiology of KFD.

Kikuchi-Fujimoto disease (KFD; syn: Kikuchi’s disease, histiocytic necrotizing lymphadenitis), a rare self-limiting disorder of uncertain etiology, presents with prolonged lymphadenopathy with or without systemic features. The exact role of microbial infection and other non-infectious triggers in its etiopathogenesis remains obscure.

2020年3月16日 · Less often, KFD can present with axillary and mesenteric lymphadenopathy, splenomegaly, parotid gland enlargement, arthralgia, myalgia, and interstitial lung disease. Diagnosis of KFD is made when a lymph node biopsy shows necrotizing lymphadenitis with karyorrhexis and absence of granulocytes.

In conclusion, we characterised brain lesions especially related to KFD. An increased level of IFN-α in CSF without viral infection also seems to be an important feature of KFD. A diagnosis of KFD is important to consider because it often goes into spontaneous remission, although corticotherapy is sometimes necessary in more severe cases.

2024年9月21日 · Background Kikuchi-Fujimoto disease (KFD) is a benign lesion of the lymph nodes predominantly seen in younger women and is a condition associated with a good prognosis due to its indolent nature. Since KFD is chiefly a diagnosis of exclusion, it is liable to a higher degree of misdiagnosis.

2023年7月1日 · Only a small proportion of patients with KFD had autoimmune diseases or infections from specific pathogens, suggesting that KFD is likely a reactive lesion of lymph nodes to various circumstances. To our knowledge, this is the first and the largest study to detect pathogens with the use of mNGS on F …

Aims: Kikuchi-Fujimoto disease (KFD) is a rare dis-ease that typically manifests with fever and cervical lymphadenopathy. Little is known about the risk fac-tors associated with recurrence and their correlation with clinicopathologic features.

2012年7月27日 · Neurological manifestations have been reported in Kikuchi–Fujimoto disease (KFD). Characteristics of brain lesions are not defined. In addition, no biological indexes are known to help clinicians along the diagnosis process. The authors describe encephalitis associated with KFD.

FDG PET/CT will be useful for detecting noncervical lesions of KFD and distinguishing KFD from NHLs using both SUV and corSUV. KFD shows high FDG uptake for size, which may reflect the pathologic characteristics, including necrotizing lymphocytes and numerous histiocytes (macrophages) surrounding small necrotic foci.

2023年5月3日 · Kikuchi-Fujimoto Disease (KFD) or histiocytic necrotizing lymphadenitys is a rare, benign self-limited disorder characterized by subacute necrotizing regional lymphadenopathy. It was thought that it commonly affected young Asian adults, mainly females.