2013年9月27日 · If you would look up the properties of KHMDS from a chemical supplier, you will find it will react violently with with water. So do keep it under inert atmosphere. As for solubility, …

2016年7月28日 · And yet, the reaction conditions are KHMDS/18-crown-6 which are clearly designed to eliminate the possibility of coordination to the potassium cation and maximise the …

2020年12月27日 · $\begingroup$ i understand step (a) follows The Mitsunobu reaction, and steps (d) and (e) gives the aldehyde moiety in the final product, im stuck on how the C=C is formed …

2024年1月28日 · The book is correct. This is a classic example of a 1,4-addition (also called a conjugate addition) of an alkyl nucleophile to an α,β-unsaturated ketone.

2016年2月18日 · Dry ice (solid carbon dioxide) sublimes at −78 °C. Dry ice and acetone are a common cold bath for chemical reactions.

2019年1月18日 · Ammonium chloride ($\ce{NH4Cl}$) is the work-up reagent that quenches the magnesium alkoxide product of the Grignard addition.

2014年12月21日 · $\begingroup$ Jori that's an excellent question. The enolization process that you refer to (e.g. removal of an alpha proton) is very different from carbonyl addition.

2017年12月31日 · According to the current version of Nomenclature of Organic Chemistry – IUPAC Recommendations and Preferred Names 2013 (Blue Book), as already mentioned in …