In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are …

IκB（inhibitor of NF-κB），是核因子κB（NF-κB）的抑制蛋白。 IκB家族由8个成员组成，分别是：p100、p105、IκBα、IκBβ、IκBγ、IκBε、Bcl-3和IκB-R，大部分IκB的 C端 含有3~8个 锚蛋 …

We describe here how these studies have identified a unique inhibitor of pro-inflammatory NF- κ B signaling, an unforeseen role for IKK α in the classical NF- κ B pathway, and a novel functional …

IκB 激酶（IκB kinase;IKK）是一个生物化学与分子生物学名词。 一种丝氨酸特异的蛋白激酶，由多组分构成。 可被细胞外刺激激活、催化IκB (NF-κB的抑制蛋白)特异位点的磷酸化，导致IκB …

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the …

New work reveals the roles of the three subunits of IKK and how it is regulated. NF-κB represents a family of transcription factors that are normally kept inactive in the cytoplasm through …

2019年10月19日 · Control over the immune cell functions of NF-κB results from signaling through one of two different routes: the canonical and noncanonical NF-κB signaling pathways. …

In the present chapter, we review the structural information available on NF-κB, IκB, and IKK, the critical terminal components of the NF-κB signaling, in relation to their physiological function. …

抑制性 kappa B 激酶 beta (IKKβ)，称为 IKK2，是一种关键的调节激酶，通过其 Ser177 和 Ser181 磷酸化来激活 NF-κB，从而促进 kappa B 抑制剂 (IκB) 的磷酸化，触发其泛素化和降解以激活 …

2011年3月7日 · IKK 复合体 (IKB 激酶)是 NF — KB 信 号通路的主要调节物 ，它由三个亚基组 成 ： 催化亚基 IKKc~(IKK 1) 、 IKKf~(IKK2) 和 调 节 亚 基 IKK'ymodulator)。 oI、 8 亚单位在其 …