2023年9月10日 · Ki-67 is a protein found in the nucleus of cancer cells that are actively growing and dividing. For breast cancer, Ki-67 is one of the main tumor biomarkers that your healthcare provider will check for when diagnosing, staging, and monitoring the cancer.

Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and its cellular distribution dramatically changes during cell cycle progression.

Patients with Ki-67 higher than 15% exhibited higher incidence of metastasis and recurrence than those with Ki-67 less than 15% (P = 0.000). Conclusions: Ki-67 may be considered as a valuable biomarker in breast cancer patients.

In breast cancer development, the expression of Ki-67 is strongly associated with cancer proliferation and is a known indicator of prognosis and outcome. Ki-67 expression levels are also useful to inform treatment decision making in some cases. As a ...

A Ki-67 proliferation index over 30% is typically considered high. The Ki-67 proliferation index may be used to help predict how well some cancers, such as breast cancer, will respond to certain treatments, such as chemotherapy. Also called Ki-67 score.

2024年10月23日 · The KI-67 protein test is a diagnostic tool used in the field of oncology to measure the level of a protein called KI-67 in cancer cells. The KI-67 protein is a marker for cell proliferation, meaning it indicates how quickly cancer cells are dividing and growing.

2022年3月14日 · Her tumor had a higher level of a cancer-related gene known as Ki-67, indicating rapid reproduction of cancer cells. A mixed bag of clinical trial data has shown that certain levels of Ki-67 in breast tumors support better outcomes for patients who are treated with CDK inhibitors.

The nuclear protein Ki67 (pKi67) is an established prognostic and predictive indicator for the assessment of biopsies from patients with cancer. Clinically, pKi67 has been shown to correlate with metastasis and the clinical stage of tumors.

2024年1月31日 · The Ki-67 test is used in breast cancer to measure the rate of cell proliferation or growth in tumor tissues. Measuring a specific protein associated with cancer cell growth may help...

2021年6月28日 · We describe how expression of the MKI67 gene coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are maximally expressed in G 2 phase and mitosis. Expression is...