If it's fun for kids, you'll find it here! His favorite toys are Paw Patrol and Hot Wheels. We also love to dress up as Super Heroes and costumes and have some pretend play fun and play fun games...

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2020年9月7日 · In this study, the structural ensembles and binding process of pKID and KIX are studied by all-atom enhanced sampling technologies. The results show that more hydrophobic interactions are formed...

2020年10月29日 · 该研究揭示KID与KIX结合的分子机制，为磷酸化修饰调控蛋白质的结构和功能提供新思路。 相关研究成果发表在《通讯-化学》（Communications Chemistry）上，该研究选入自然出版网站上的“behind the paper”频道，发表post进一步阐述。 博士研究生刘娜、郭玥为论文的共同第一作者，段谟杰为论文通讯作者。 研究工作得到国家自然科学基金的资助。 磷酸化之后的pKID与KIX结合过程的自由能变化图。 从未结合的自由态（F态）到完全结合态（B态），需 …

2020年11月1日 · 近日，中国科学院精密测量科学与技术创新研究院理论与计算化学组副研究员段谟杰等利用计算模拟方法及增强采样技术，揭示磷酸化修饰对固有无 ...

2004, the year Kid Pix Deluxe 4 was released on Windows, as well as Mac. Made by Learning Company, The and published by Riverdeep Interactive Learning Limited, Learning Company, The, this educational game is available for free on this page.

2021年10月9日 · Kid Pix Studio is a creativity computer game which updates the look of the previous Kid Pix 2 version with new animation tools, including Moopies, Stampinator, and playing with the Digital Puppets. Moopies is where the child …

Kid Kix, Waller, Texas. 81 likes · 1 talking about this · 4 were here. Kid Kix is dedicated to enhancing the development of children and teens, by providing recreational gymnastics classes and...

2013年11月16日 · In this article, we review the KIX domain in terms of its sequence and structure and present the various implications of its ability to act as a transcriptional switch, the mechanistic basis of molecular recognition by KIX, its binding specificity, target promiscuity, combinatorial potential and unique mode of regulation via allostery.

CREB激酶诱导结构域（KID）的Ser-133处的磷酸化通过伴随的从线圈到螺旋的转变触发其与CBP的KIX结构域的结合。 这个关键事件的确切作用仍然令人费解：它不会在无序状态和有序状态之间切换，也不会直接相互作用来充分说明选择性。 因此，我们认为磷酸化可能会使KID的构象偏爱向结合态迁移。 为此，我们通过模拟退火和分子动力学模拟研究了磷酸化和非磷酸化形式的未结合KID的固有结构性质。 尽管螺旋种群显示出细微的差异，磷酸化降低了在复杂结构中连接两 …