2024年12月25日 · KIF2A (Kinesin Family Member 2A) is a Protein Coding gene. Diseases associated with KIF2A include Cortical Dysplasia, Complex, With Other Brain Malformations 3 and Non-Syndromic Pontocerebellar Hypoplasia. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Golgi-to-ER retrograde transport.

摘 要：驱动蛋白家族成员2a (kif2a)是一种能够与微管相互作用的蛋白，它参与了细胞内物质运输、细 胞迁移、细胞形态改变，以及有丝分裂细胞纺锤体动力学等重要的细胞活动。

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene. [5] [6] In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons. [7] Kinesins, such as …

Ras regulates KIF2A to control cell migration pathways in transformed human bronchial epithelial cells. KIF2A may play an important role in breast cancer progression and is potentially a novel predictive and prognostic marker for breast cancer.

2021年6月7日 · Title: The minus-end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules. Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer.

2016年12月19日 · KIF2A, a member of the kinesin-13 family, has been reported to play a role in spindle assembly in mitosis. However, its function in mammalian meiosis remains unknown. In this research, we...

The human genome has three unique genes coding for kinesin-13 proteins called Kif2a, Kif2b, and MCAK (Kif2c). Kif2a and MCAK have documented roles in mitosis, but the function of Kif2b has not been defined. Here, we show that Kif2b is expressed at very low levels in cultured cells and that GFP-Kif2b …

Kinesin family protein 2A (KIF2A), an M-type nonmotile microtubule depolymerase, plays essential roles in development and progression of various human cancers. However, its exact function and the underlying mechanism in tumorigenesis of …

2023年8月30日 · 驱动蛋白超家族成员2A（KIF2A） 是人类驱动蛋白 13 基因家族中的一个成员，它能使微管解聚和不稳定。 在分裂细胞中，KIF2A参与有丝分裂进程和染色体分离。 在有丝分裂后的神经元中，轴突/树突的分化和延伸、神经元迁移、连接和存活都需要它。 KIF2A基因突变与大脑皮层发育畸形、癫痫、自闭症谱系障碍和神经退行性变有关。 比利时鲁汶天主教大学神经科学研究所的Fadel Tissir等在发表于《中国神经再生研究（英文版）》2024年第2期的综述文章中讨 …

由该基因编码的蛋白质是正常有丝分裂进程所需的正末端定向马达。 编码的蛋白质是有丝分裂期间正常纺锤体活动所必需的，也是正常大脑发育所必需的。 已发现该基因编码不同亚型的几种转录变体。 [RefSeq 提供，2011 年 9 月] The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development.