In biochemistry, a kinase (/ ˈ k aɪ n eɪ s, ˈ k ɪ n eɪ s,-eɪ z /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

Kinase, an enzyme that adds phosphate groups to other molecules. A large number of kinases exist, the human genome alone containing hundreds of kinase-encoding genes. Included among kinase targets for phosphorylation are proteins, lipids, and nucleic acids.

A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.

In this Special Issue “Protein Kinases: Function, Substrates, and Implication in Diseases”, we collected seven review papers and five original research articles, focused on new findings, recent advances and future development in the protein kinase field.

2022年3月3日 · Regulation and Function of Protein Kinase. There are about 500 protein kinase encoding genes in the human genome which represents 2% of all the human genes. Kinase is the name given to an enzyme that adds a phosphate group (PO 4 3-) to other biomolecules such as protein, lipid, or nucleotides. This type of addition of a phosphate group is ...

2023年12月1日 · What is a Kinase and How Does it Work in the Cell. Kinases are enzymes that help regulate cells of all living organisms by controlling signal transduction pathways. In essence, they act as a catalyst to “switch on/off” various cellular functions including metabolism and growth.

Protein and lipid kinases represent an important target class for treating human disorders. This review focus on ‘the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery.

Protein kinases and phosphatases are enzymes catalysing the transfer of phosphate between their substrates. A protein kinase catalyses the transfer of γ-phosphate from ATP (or GTP) to its protein substrates while a protein phosphatase catalyses the transfer of the phosphate from a phosphoprotein to a water molecule. Even though both groups of ...

6 天之前 · Well-known members include protein kinase A (PKA), protein kinase C (PKC), and mitogen-activated protein kinases (MAPKs). MAPKs are central to signal transduction pathways that respond to extracellular stimuli such as growth factors and stress signals. They function in cascades, where one kinase activates another, amplifying the signal.

2020年5月6日 · Here we discuss structural elements of the kinase active site, key mechanisms of kinase regulation and how these mechanisms can be exploited for the development of selective kinase inhibitors. Download chapter PDF

A kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates. From: The World’s Health Care Crisis, 2011

2024年12月19日 · The role of kinase inhibitors in therapeutics within the context of protein kinase-mediated cellular signaling, with a focus on relevant studies and clinical applications, will be addressed in this topic.

2023年6月13日 · Prominent examples include the mitogen-activated protein kinase kinase (MAP2K or MEK) family and the dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). Protein kinases can be further classified according to their function.

1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor, and named, according to the acceptor, as creatine kinase, fructokinase, etc.

2024年12月20日 · The meaning of KINASE is any of various enzymes that catalyze the transfer of phosphate groups from a high-energy phosphate-containing molecule (such as ATP) to a substrate.

2010年9月10日 · The kinase reaction Protein Kinases bind substrate proteins and ATP and transfer a phosphate group from ATP to amino acids with free hydroxyl (-OH) groups ( serine , threonine or tyrosine ). The products are the phospho-protein and ADP .

Susan Taylor gives an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily.

4 天之前 · From this perch, PINK1’s kinase domain springs into action, phosphorylating ubiquitin, which recruits the ubiquitin ligase Parkin—another PD-linked protein—to tag mitochondria for degradation. While the broad strokes of this process are well-known, precisely how PINK1 remains anchored to the membranes of ailing mitochondria was a puzzle.

Kinases are particularly prominent in signal transduction and co-ordination of complex functions such as the cell cycle. The diversity of essential functions mediated by kinases is shown by the conservation of some 50 distinct kinase families between yeast, …

2021年8月30日 · KinBase holds information on the 1800 protein kinase genes found in the genomes of human, fruit fly (Drosophila melanogaster), nematode worm (Caenorhabditis elegans), and yeast (Saccharomyces cerevisiae) .