In biochemistry, a kinase (/ ˈ k aɪ n eɪ s, ˈ k ɪ n eɪ s,-eɪ z /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

In this Special Issue “Protein Kinases: Function, Substrates, and Implication in Diseases”, we collected seven review papers and five original research articles, focused on new findings, recent advances and future development in the protein kinase field.

kinase, an enzyme that adds phosphate groups (PO 43−) to other molecules. A large number of kinases exist—the human genome contains at least 500 kinase-encoding genes. Included among these enzymes’ targets for phosphate group addition (phosphorylation) are …

2023年12月1日 · Kinases are enzymes responsible for relaying signals in and out of cells, allowing them to respond adaptively to their environment. Kinases influence almost all cellular activities, ranging from proliferation and remodeling to differentiation and programmed cell death.

For instance, overactive protein kinases, including mutated or overexpressed kinases in cancer, can be targeted by protein kinase inhibitors to treat cancers and regulate cellular function. Additionally, protein kinase inhibitors show potential in treating autoimmune diseases, organ transplantation, and neurological disorders by modulating ...

2022年3月3日 · Regulation and Function of Protein Kinase. There are about 500 protein kinase encoding genes in the human genome which represents 2% of all the human genes. Kinase is the name given to an enzyme that adds a phosphate group (PO 4 3-) to other biomolecules such as protein, lipid, or nucleotides. This type of addition of a phosphate group is ...

A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.

2011年10月28日 · Here, we discuss such kinase independent functions of protein and lipid kinases focussing on kinases that play a role in the regulation of cell proliferation, differentiation, apoptosis, and motility.

A protein kinase catalyses the transfer of γ-phosphate from ATP (or GTP) to its protein substrates while a protein phosphatase catalyses the transfer of the phosphate from a phosphoprotein to a water molecule. Even though both groups of enzymes are phosphotransferases, they catalyse opposing reactions to modulate the structures and functions ...

Protein kinases (PKs), belonging to the kinase family, are a kind of phosphotransferases responsible for the transfer of the γ-phosphate from ATP to the specific amino acid residues of the substrate proteins.

3 天之前 · Protein Kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families. By adding phosphate groups to substrate proteins, they direct the activity, localization and overall function of many proteins, and serve to orchestrate the activity of almost all cellular processes.

In this lecture, I have given an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily.

2010年9月10日 · Protein Kinases are enzymes that modify the function of other proteins by attaching phosphate groups to them. They are key controllers of most biochemical pathways and important in health and disease.

Protein kinases are master regulatory switches that control the growth and proliferation of cells. In response to specific metabolic signals, protein kinases phosphorylate and activate target proteins that amplify the signal into cellular growth cascades.

Protein kinase is a type of enzyme that modifies other proteins by adding phosphate groups to them. This phosphorylation process is essential for the regulation of cellular activities such as cell signaling, gene expression, and metabolism.

Protein kinases are enzymes that catalyze the transfer of phosphate groups to specific amino acid residues in target proteins, mainly serine, threonine, and tyrosine. This phosphorylation event modifies the structure and function of the target protein, either activating or inhibiting its activity.

A kinase is an enzyme that plays a crucial role in cell signaling pathways by adding a phosphate group to other molecules, typically proteins. This process, known as phosphorylation, can activate or deactivate target proteins, regulating various cellular processes.

2025年2月28日 · As the CDK (cyclin-dependent kinase) activating kinase (CAK), CDK7 phosphorylates and activates CDK4/6, CDK1, and CDK2, which act in the nucleus and cytoplasm to regulate the cell cycle (1–3).As part of the 10-subunit TFIIH complex, CDK7 also regulates RNA polymerase II (RNAPII) transcription through phosphorylation of the RNAPII C-terminal domain …

Kinases are enzymes that catalyze the transfer of phosphate groups from high-energy donor molecules, such as ATP, to specific substrates. This process is essential for various cellular functions, including the regulation of metabolic pathways, signal transduction, and the modulation of protein activity.

2025年3月12日 · The protein kinase Mps1 (also known as TTK) is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures accurate chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bioriented on the mitotic spindle. Mps1 kinase is an important …