Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. [1][2] In humans, they are encoded in the leukocyte receptor complex (LRC) on chromosome 19q13.4; the KIR region is approximately 150 kilobases and contains ...

2024年12月25日 · KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) is a Protein Coding gene. Diseases associated with KIR3DL1 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and …

2019年5月27日 · KIR Genes Display an Extraordinary Level of Polymorphism. KIR gene family is characterized by an extraordinary high degree of diversity, which arises from variability in KIR gene content, due to differences in both presence/absence (P/A) of KIR genes and KIR gene copy number, and from allelic polymorphism (80–89).

2003年5月28日 · KIR genes are tandemly arrayed over about 150 kb, with the remarkable feature that gene content varies between haplotypes. The discovery of KIR has also imparted an additional function on the human leukocyte antigen (HLA) class I molecules, which are encoded by genes within the major histocompatibility complex (MHC; chromosome 6).

2024年2月28日 · 杀伤细胞免疫球蛋白样受体（Killer Cell Immunoglobulin-like Receptors, KIR，即CD158）是一个由14个多态性基因编码的受体家族（KIR2DL1 、 2DL2 、 2DL3 、 2DL4 、2DL5； KIR3DL1 、 3DL2 、 3DL3； KIR2DS1 、 2DS2 、 2DS3 、 2DS4 、 2DS5； KIR3DS1）。 KIR家族的成员被分为两种类型：KIR2D和KIR3D。 KIR的命名基于其胞外区的结构特征（2D vs 3D，代表胞外免疫球蛋白样区域的数目）和胞质尾区的长度（L，长vs S，短） …

KIR genes are classified as belonging to one of three groups according to their structural features: 1) Type I KIR2D genes, which encode two extra-cellular domain proteins with a D1 and D2 conformation; 2) The structurally divergent Type II KIR2D genes which encode two extra-cellular domain proteins with a D0 and D2 conformation and finally; 3) ...

The IPD-KIR Database provides a centralised repository for human KIR sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic and haplotypic level.

2017年6月1日 · We present a unique approach to haplotype the KIR loci using single-molecule, real-time (SMRT) sequencing. Using this method, we have—for the first time—comprehensively sequenced and phased...

2025年3月4日 · Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).

4 天之前 · High KIR gene density and sequence similarity may impact recombination rates. In most organisms, an elevated recombination rate is positively correlated with gene density. 52–54 The architecture of the KIR region is characterized by a head-to-tail organization in which densely packed genes are separated only by relatively short intergenic ...