2024年2月28日 · 杀伤细胞免疫球蛋白样受体（Killer Cell Immunoglobulin-like Receptors, KIR，即CD158）是一个由14个多态性基因编码的受体家族（KIR2DL1、2DL2、2DL3、2DL4 …

2021年2月2日 · 杀伤细胞免疫球蛋白样受体（ kir s）在记忆性t细胞和nk细胞上表达，是 nk细胞功能的关键调节因子 。kir及其配体mhc-i类（hla-a、-b、-c）分子具有高度多态性，特殊的相互 …

The IPD-KIR Database provides a centralised repository for human KIR sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic …

2024年12月1日 · We hypothesize that a critical discriminating factor in KIR–HLA-I interactions is the selective detection of HLA-I-bound peptides by KIRs. We propose a ‘peptide selectivity …

Combinations of HLA and killer cell immunoglobulin–like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and …

本文从基础hla和kir生物学知识开始，回顾分析国外多年积累的临床数据，以期对这一话题进行一个详细的总结。 目录. 一、hla的生物学原理. 二、kir的生物学原理. 三、利用hla与kir的匹配性优 …

2020年3月17日 · HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity, which is associated with endometriosis...

2022年7月1日 · Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

2 天之前 · Here, we present kir-mapper, a toolkit to analyse KIR genes from short-read sequencing, focusing on detecting KIR alleles, copy number variation, as well as SNPs and …

Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive immunity. The …