2024年2月28日 · 杀伤细胞免疫球蛋白样受体（Killer Cell Immunoglobulin-like Receptors, KIR，即CD158）是一个由14个多态性基因编码的受体家族（KIR2DL1、2DL2、2DL3、2DL4、2DL5；KIR3DL1、3DL2、3DL3；KIR2DS1、2DS2、2DS3、2DS4、2DS5；KIR3DS1）。KIR家族的成员被分为两种类型：KIR2D和KIR3D。

2021年2月2日 · 杀伤细胞免疫球蛋白样受体（ kir s）在记忆性t细胞和nk细胞上表达，是 nk细胞功能的关键调节因子 。kir及其配体mhc-i类（hla-a、-b、-c）分子具有高度多态性，特殊的相互作用会影响一些疾病的发生率、进展和结果，如妊娠并发症、病毒感染、自身免疫性疾病和 ...

The IPD-KIR Database provides a centralised repository for human KIR sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic and haplotypic level.

2024年12月1日 · We hypothesize that a critical discriminating factor in KIR–HLA-I interactions is the selective detection of HLA-I-bound peptides by KIRs. We propose a ‘peptide selectivity model’, where high-avidity KIR–HLA-I interactions reflect low selectivity for peptides conferring consistent NK cell inhibition across different tissue immunopeptidomes.

Combinations of HLA and killer cell immunoglobulin–like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations ...

本文从基础hla和kir生物学知识开始，回顾分析国外多年积累的临床数据，以期对这一话题进行一个详细的总结。 目录. 一、hla的生物学原理. 二、kir的生物学原理. 三、利用hla与kir的匹配性优化hsct移植的临床依据. 四、同种异体nk细胞免疫治疗的匹配原则及应用实例

2020年3月17日 · HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity, which is associated with endometriosis...

2022年7月1日 · Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive immunity. The extreme diversity of this interaction is genetically determined, having evolved in the ever-changing environment of pathogen exposure.

2 天之前 · Here, we present kir-mapper, a toolkit to analyse KIR genes from short-read sequencing, focusing on detecting KIR alleles, copy number variation, as well as SNPs and InDels in the context of the hg38 reference genome. kir-mapper can be used with whole-genome sequencing (WGS), whole-exome sequencing (WES) and sequencing data generated after ...

Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive immunity. The extreme diversity of this interaction is genetically determined, having evolved in the ever-changing environment of pathogen exposure.