Channelpedia - Kir3.4 - EPFL
KCNJ5 (also known as CIR; GIRK4; KATP1; LQT13; KIR3.4) encodes Kir3.4, a potassium inwardly-rectifying channel, subfamily J, member 5. This integral membrane protein has a …
Crystal Structure of the Mammalian GIRK2 K - Cell Press
2011年9月30日 · G protein-gated K + channels (Kir3.1–Kir3.4) control electrical excitability in many different cells. Among their functions relevant to human physiology and disease, they …
Next-generation inward rectifier potassium channel modulators ...
2021年6月18日 · Inward rectifying potassium (Kir) channels play important roles in both excitable and nonexcitable cells of various organ systems and could represent valuable new drug …
Insight into the Phospholipid-Binding Preferences of Kir3.4
2021年11月30日 · The G-protein-gated inwardly rectifying potassium channel 4 (Kir3.4) subunit forms functional tetramers. Previous studies have established that phosphatidylinositol 4,5 …
慢性房颤患者心房肌细胞KAch通道Kir3.4基因和蛋白表达变化及机 …
目的研究慢性房颤(AF)患者心房肌细胞乙酰胆碱敏感钾通道(KAch)Kir3.4基因及 蛋白表达变化,探讨其在AF离子通道重构机制中的作用.方法选择22例心脏瓣膜病手术患者,根据基础心律分为AF …
Kir Channel Molecular Physiology, Pharmacology, and Therapeutic ...
2021年8月4日 · RT-qPCR revealed that in CA3-CA1 hippocampal neurons application of Aβ decreased mRNA transcripts for Kir3.2, Kir3.3, and Kir3.4 subunits (Mayordomo-Cava et al. …
Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome
2010年6月11日 · A heterozygous mutation (Kir3.4-Gly387Arg) was identified in the G protein-coupled, inwardly rectifying potassium channel subunit Kir3.4, encoded by the KCNJ5 gene. …
壹生资讯-首次发现“自身免疫性房颤”或与Kir3.4抗体有关！
2023年8月30日 · K ir 3.4免疫小鼠的电生理研究表明， K ir 3.4 自身抗体显著缩短了心房有效不应期，使动物对房颤的易感性增加了2.8倍。 中国医学论坛报焦桐编译并整理 评论
KIR3.4 抑制因子 | SCBT - Santa Cruz Biotechnology
KIR3.4抑制剂是一组独特的化学物质，对KIR3.4离子通道具有特异性亲和力，而KIR3.4离子通道是广泛分布于各种细胞类型中的内向整流钾通道亚型。 这些抑制剂通过与KIR3.4通道的结构和 …
The Potassium Channel, Kir3.4 Participates in Angiotensin II …
2012年7月13日 · The Kir3.4 channel, product of the KCNJ5 gene, regulates potassium flow and the membrane voltage and is gated by G protein-coupled receptors (14–16). Our results …