
Kir6.2 - Wikipedia
It is an integral membrane protein. The protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated …
Kir6.2 is essential to maintain neurite features by modulating …
Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal therapeutic target for multiple …
未来技术学院陈雷课题组报道胰岛KATP通道受核苷酸调控的结构机制
2022年5月28日 · 胰岛β细胞中的k atp 通道由kir6.2亚基和sur1亚基组成,通过直接感受细胞内atp/adp的浓度比例,间接感受血糖浓度,从而调控胰岛素的释放。 靶向胰岛KATP通道的胰 …
ATP敏感钾通道 - 百度百科
Kir6.2 主要在心室肌和 内皮细胞 中表达,而 平滑肌细胞 中没有表达。 SUR1 在 心室肌细胞 表面强表达(但是冠脉系统中无表达), 而SUR2 主要在心肌和冠状动脉血管(主要是小血管)表达。
Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K
Here we show that the Kir6.2 pore-forming subunit is significantly overexpressed in the astrocytes of human BC specimens, and we speculate about Kir6.2's potential role in the pathophysiology …
Kir6.2 - an overview | ScienceDirect Topics
Kir6.2 is a subtype of inwardly rectifying potassium channels that contribute to regulating the resting membrane potential and controlling excitability in various cells. It forms part of KATP …
Structure of an open KATP channel reveals tandem PIP2 binding …
2024年3月20日 · Here, we report the cryoEM structure of a KATP channel harboring the neonatal diabetes mutation Kir6.2-Q52R, in the open conformation, bound to amphipathic molecules …
Focus on Kir6.2: a key component of the ATP-sensitive ... - PubMed
Gain-of-function mutations in Kir6.2 cause permanent neonatal diabetes mellitus (PNDM) by reducing the ATP sensitivity of the K (ATP) channel and increasing the K (ATP) current, which …
开放 KATP 通道的结构揭示了介导 Kir6.2 和 SUR1 调节界面的串联 …
Here, we report the cryoEM structure of a K channel harboring the neonatal diabetes mutation Kir6.2-Q52R, in the open conformation, bound to amphipathic molecules consistent with …
Kir6.2 is essential to maintain neurite features by modulating …
2021年10月15日 · Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal …