It is an integral membrane protein. The protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated …

Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal therapeutic target for multiple …

2022年5月28日 · 胰岛β细胞中的k atp 通道由kir6.2亚基和sur1亚基组成，通过直接感受细胞内atp/adp的浓度比例，间接感受血糖浓度，从而调控胰岛素的释放。 靶向胰岛KATP通道的胰 …

Kir6.2 主要在心室肌和 内皮细胞 中表达，而 平滑肌细胞 中没有表达。 SUR1 在 心室肌细胞 表面强表达(但是冠脉系统中无表达), 而SUR2 主要在心肌和冠状动脉血管（主要是小血管）表达。

Here we show that the Kir6.2 pore-forming subunit is significantly overexpressed in the astrocytes of human BC specimens, and we speculate about Kir6.2's potential role in the pathophysiology …

Kir6.2 is a subtype of inwardly rectifying potassium channels that contribute to regulating the resting membrane potential and controlling excitability in various cells. It forms part of KATP …

2024年3月20日 · Here, we report the cryoEM structure of a KATP channel harboring the neonatal diabetes mutation Kir6.2-Q52R, in the open conformation, bound to amphipathic molecules …

Gain-of-function mutations in Kir6.2 cause permanent neonatal diabetes mellitus (PNDM) by reducing the ATP sensitivity of the K (ATP) channel and increasing the K (ATP) current, which …

Here, we report the cryoEM structure of a K channel harboring the neonatal diabetes mutation Kir6.2-Q52R, in the open conformation, bound to amphipathic molecules consistent with …

2021年10月15日 · Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal …