2023年2月24日 · 激活性受体包括激活性杀伤细胞Ig样受体（KIR）、活化性受体（NKG2D）以及自然细胞毒性受体（NCR），激活性KIR可识别经典型的MHC-I类分子，而NKG2D则识别非经典型MHC-I类分子。 抑制性受体包括抑制性KIR和异源二聚体NKG2A/CD94受体，抑制性KIR可识别经典MHC-I类分子，而NKG2A/CD94则识别非经典MHC-I分子。 MHC-I抗原特异性的抑制性受体，可密切调节NK细胞介导的细胞毒性和淋巴因子的产生。 一些KIR家族成员（KIR2DL1/2/3/5 …

Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells.

2021年2月2日 · 杀伤细胞免疫球蛋白样受体（KIRs）在记忆性T细胞和NK细胞上表达，是NK细胞功能的关键调节因子。 KIR及其配体MHC-I类（HLA-A、-B、-C）分子具有高度多态性，特殊的相互作用会影响一些疾病的发生率、进展和结果，如妊娠并发症、病毒感染、自身免疫性疾病和血液系统恶性肿瘤。 因此，深入了解KIR-MHC-I类相互作用的分子机制有助于疾病的治疗策略。 NK细胞受体与配体. 根据基因表型与数量，KIRs分为两种单倍型 (haplotype)：A和B。 A单倍型包 …

2024年12月1日 · We know that viral-derived peptides can bind KIRs, but do they matter for KIR + NK cell responses to infected cells? How did peptide selectivity by KIRs evolve? Do other primate KIRs exhibit similar peptide selectivity properties or is the latter unique to human KIRs?

2016年12月2日 · Accumulating data indicate that epistatic interactions between KIR and HLA influence outcomes in several clinical conditions. Herein, we discuss the genetic and functional features of KIR/KIR-ligand interactions in hematopoietic stem cell transplantation and how these data can guide donor selection.

2023年3月28日 · Subsets of the human CD8 + T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A. In the present study, we examine the phenotypic and functional characteristics of …

2018年11月9日 · Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory KIRs can also affect adaptive T cell-mediated immunity.

2024年11月21日 · Recent data have exposed differences between killer-cell immunoglobulin-like receptors (KIRs) in their selective binding to human leukocyte antigen (HLA) class I (HLA-I)-bound peptides. These differences range from being peptide …

2017年5月25日 · In particular, donor-derived KIR2DS1+ NK cells were shown to efficiently kill HLA-C2+ leukemia blasts, which indicate that activating KIRs can have a role in mediating anti-leukemic or...

2022年8月20日 · Adaptive natural killer (NK) cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs) can be expanded in vivo in response to human cytomegalovirus (HCMV) infection. Developing a method to preferentially expand this subset is essential for effective targeting of allo …