Measuring kLa for Better Bioreactor Performance
2012年3月1日 · Measurements of kLa provide important information about a bioprocess or bioreactor. These determinations ensure that processing conditions are such that an adequate …
Estimation of volumetric mass transfer coefficient (kLa…
2020年3月15日 · Significant research efforts have been expended over the last decades in order to develop reliable and easy to apply methodologies for determining kL a using aeration …
A practical approach in bioreactor scale-up and process ... - PubMed
We evaluated the sparger kLa and kLaCO2 (CO 2 volumetric mass transfer coefficient) from a range of bioreactor scales (3-2,000 L) with different spargers. Results demonstrated that kLa …
What the kLa tells you about the oxygen transfer in your bioreactor
2021年10月24日 · The OTR is defined by the kLa and the difference between the oxygen concentration of the introduced gas and the oxygen concentration in the medium:
Correlation between mass transfer coefficient kLa and relevant ...
2013年12月2日 · Since there is no known universal correlation between the volumetric mass transfer coefficient for oxygen k L a and relevant operating parameters in such bioreactor …
(PDF) KLa measurement in bioreactors - ResearchGate
2010年1月1日 · A dynamic method of measuring the volumetric mass transfer coefficient of oxygen, kLa, in gas-liquid reactors is presented which consists in monitoring simultaneously …
(PDF) Experimental Determination of the Volumetric Mass …
2013年5月15日 · In this study, it was clarified that a high kLa of 300 h⁻¹ or higher can be measured by a static method using an optical dissolved oxygen sensor with a remarkably fast …
Estimation of kLa and P/V for 250mL and 5L Mammalian Bioreactors
In this study, we quantify the volumetric mass transfer coefficient of oxygen (kLa) and specific power input (P/V) in bioreactors. These are essential parameters that define a bioreactor's …
Oxygen Uptake Rate Soft-Sensing via Dynamic kLa Computation: …
In this study, a 15 L mammalian cell culture bioreactor was characterized with respect to k L a under varying process conditions. The resulting dynamic k L a description combined with …
体积传质系数 (kLa) 的估计 - 经典方法的回顾和新方法的贡 …
2020年3月1日 · 在过去的几十年中，为了开发可靠且易于应用的方法来使用曝气实验和快速氧气（极谱）探针确定 kLa，已经进行了大量的研究工作。 本研究对这些方法进行了审查，然后介 …