2024年12月25日 · KLRC2 (Killer Cell Lectin Like Receptor C2) is a Protein Coding gene. Diseases associated with KLRC2 include Human Cytomegalovirus Infection and Nk Cell Deficiency . Among its related pathways are DAP12 interactions and Innate Immune System .

NKG2-C type II integral membrane protein or NKG2C is a protein that in humans is encoded by the KLRC2 gene. [3] [4] It is also known as or cluster of differentiation 159c (CD159c).

The CD94/NKG2C receptor is encoded by the 6 kpb length NKG2C gene, also referred as KLRC2, located within the NK complex on chromosome 12p12.3–13.2 (Fig. 1). It consists of six exons and five introns.

Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19. Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients.

klrc (nkg2) 基因家族位于 nk 复合体中，该区域包含优先在 nk 细胞上表达的几个 c 型凝集素基因。已经描述了 klrc2 替代剪接变体，但尚未确定其全长性质。[refseq 提供，2008 年 7 月]

2023年10月18日 · 新的研究揭示了肿瘤进展过程中全身免疫的改变。研究者的研究发现了一种 CD56dimCD16hi c8-KLRC2 适应性 NK 细胞群，其特征是肿瘤患者外周血中某些促炎细胞因子和 MHC II 类基因的上调。

2025年2月8日 · The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] Expression

高表达细胞毒性基因的cd8+t细胞同时也高表达包括klrc2（nkg2c），klrc3（nkg2e），klrc1（nkg2a），klrd1（cd94）和klrb1（cd161）这些nk细胞受体。 作者又分析了另外5例病人样本发现相对于CD161-T细胞，CD161+T细胞能够高表达细胞毒性基因 (GNLY和GZMB) 和NK细胞基因 (NCR3和KLRD1) 。

KLRC2, a transmembrane activating receptor in natural killer cells, was expressed more highly in glioma-initiating cells than in neural stem cell lines or normal adult brain tissue. The q-PCR analysis revealed that expression of KLRC2 was significantly higher in brain tumor-initiating cells compared to normal brain controls.

2021年1月26日 · Heterozygous or homozygous KLRC2 deletion (KLRC2del) may naturally occur and is associated with a significantly lower or absent NKG2C expression level.