KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.

2024年12月25日 · KLRD1 (Killer Cell Lectin Like Receptor D1) is a Protein Coding gene. Diseases associated with KLRD1 include Nk Cell Deficiency and Chronic Nk-Cell Lymphocytosis. Among its related pathways are DAP12 interactions and Innate Immune System.

KLRD1 (CD94) 是一种优先在 NK 细胞上表达的抗原，由于其具有外部 C 末端而被归类为 II 型膜蛋白。 已发现该基因编码不同亚型的几种转录变体。 [RefSeq 提供，2017 年 5 月] Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation.

KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

2025年1月1日 · Results: KLRD1 exhibits significant differential expression and strong prognostic value across cancers, particularly as an independent prognostic factor in head and neck squamous cell carcinoma (HNSC). Single-cell analysis revealed high expression of KLRD1 in NK and CD8Tex cells, indicating its critical role in antitumor immune responses.

KLRD1, also known as CD94, plays a critical role in immune surveillance by forming a receptor complex with NKG2 molecules 8-10. Many factors influence the expression of KLRD1 molecules, including cytokines such as IL-12 and IFN-gamma, viral infections, and tumor factors.

KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

预测能够实现HLA-E特异性的抑制性MHC类Ib受体活性；MHC蛋白质复合物结合活性；以及蛋白质抗原结合活性。 预测参与自然杀伤细胞介导的免疫；调节白细胞介导的细胞毒性；以及刺激C型凝集素受体信号通路。 预测是受体复合物的一部分。 预测在质膜的外侧具有活性。 预测是质膜的组成部分。 与人类的KLRD1（杀伤细胞凝集素样受体D1）正同源。 [由基因组资源联盟，2022年4月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 预测能够实现HLA-E特异性的抑制 …

KLRD1（CD94）是一种优先在NK细胞上表达的抗原，被归类为II型膜蛋白，因为它具有外部C端。 已发现该基因的编码不同异构体的几个转录变异体。 [RefSeq,2017年5月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 The finished DNA sequence of human chromosome 12. Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells. TCR specificity dictates CD94/NKG2A expression by human CTL.

KLRD1（CD94）是一种优先在NK细胞上表达的抗原，由于具有外部C末端，因此被归为II型膜蛋白。 已发现该基因的几种编码不同同工型的转录物变体。 [由RefSeq提供，2017年5月] [1] KLRD1是位于12号染色体的基因。