2023年4月24日 · To this end, we have integrated a variety of tools into one harmonized R/Shiny database called MTSviewer (https://neurobioinfo.github.io/MTSvieweR/), which combines MTS predictions, cleavage sites, genetic variants, pathogenicity predictions, and N-terminomics data with structural visualization using AlphaFold models of human and yeast mitochond...

2013年4月10日 · Inhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (that is, kynurenine pathway), leads to amelioration of...

Kynurenine 3-monoox- ygenase (KMO) has a high affinity for kynurenine, suggesting that KMO metabolizes most of the available kynurenine into the neurotoxic agent 3-hydroxykynurenine...

Overall, MTSviewer is a platform that can be used to interrogate MTS mutations and their potential effects on import and proteolysis across the mitochondrial proteome. Click on the MTSviewer tab and start interrogating your favorite protein(s) listed in the dropdown menu!

kmo是做主成分分析的效度检验指标之一,以前的文献中写说,kmo在0.9以上，非常合适做因子分析；在0.8-0.9之间，很适合；在0.7-0.8之间，适合；在0.6-0.7之间，尚可；在0.5-0.6之间，表示很差；在0.5以下应该放弃.

The C-MTS of KMO is predicted as helical, solvent-accessible, and is distinct from the folded domain of KMO. Arg452 is highlighted as a variant of interest (Arg452Cys).

Kynurenine-3-monooxygenase (KMO) is a mitochondrial enzyme involved in the eukaryotic kynurenine pathway (KP), which is the major catabolic route of tryptophan. KMO can convert the substrate kynurenine into the neurotoxin 3-hydroxykynurenine and quinolinic acid, which promote the production of toxic …

2022年1月2日 · Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan. Under inflammatory conditions, however, there is an upregulation of the KP enzymes, particularly kynurenine 3-monooxygenase (KMO).

The C-MTS of KMO is predicted as helical, solvent-accessible, and is distinct from the folded domain of KMO. Arg452 is highlighted as a variant of interest (Arg452Cys). PUSL1 contains a putative N-MTS and two iMTS’s (denoted iMTS-1 and iMTS-2), which are both found within the folded domain and would likely be inaccessible for TOM70 binding in ...

2024年6月19日 · 线粒体定位信号（mitochondrial targeting signal, MTS）是一段特定的氨基酸序列，指导新合成的蛋白质从细胞质运输到线粒体。 MTS通常位于蛋白质的N端，通过识别和结合线粒体转运复合体，将蛋白质导入线粒体内腔或膜中。