2020年5月1日 · Here, we found that a thermogenic stimulus leads to enhanced secretion of kininogen (Kng) by BAT, owing to induction of kininogen 2 (Kng2) gene expression. Noradrenergic, cAMP-mediated signals...

Enables cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including negative regulation of T cell proliferation; positive regulation of cell population proliferation; and regulation of protein metabolic process. Located in extracellular space and perikaryon.

2024年12月10日 · View mouse Kng2 Chr16:22804602-22847851 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

2025年2月8日 · Gene ID: 385643, updated on 8-Feb-2025. Predicted to enable cysteine-type endopeptidase inhibitor activity; hormone activity; and protease binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and vasodilation.

We now provide the "Disease & Variants" viewer in its own tab. The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP. Go to variant viewer. Showing features for signal, modified residue, chain, disulfide bond, glycosylation, peptide. Bradykinin is released from kininogen by plasma kallikrein. Plasma.

当前研究发现，Kng2基因存在4种不同的转录本和4种不同的蛋白质变体。 该基因暂未发现相关的转录本和蛋白质序列信息。 该模块正在开发中，请耐心等待我们的数据更新。 预测能够实现半胱氨酸型内肽酶抑制剂活性；蛋白酶结合活性；以及信号受体结合活性。 预测涉及几个过程，包括由抗菌肽介导的抗菌体液免疫应答；血液凝固的负调控；以及内肽酶活性的负调控。 位于含有胶原的细胞外基质中。 这个基因的人类同源物与高分子量激肽原缺乏症有关。 与人类KNG1 (激肽 …

2020年8月1日 · We also detected higher expression of KNG1 and KNG2 mRNA in mouse liver upon invasive infection. There is a trend towards kininogen increase within 42 h of infection in mice plasma, and higher amount of kininogen degradation products suggests consumption that might be compensated in this lethal sepsis model.

Bradykinin (KNG1) exerts a proinflammatory role in local and remote inflammation during experimental acute pancreatitis. Plasma high molecular weight kininogen is key mediator of acute and chronic inflammatory arthritis in genetically susceptible Lewis rats. Enables cysteine-type endopeptidase inhibitor activity and protease binding activity.

2019年12月19日 · In human genetic association analysis, variants in genes for the bradykinin precursor (KNG1) and the bradykinin receptors (BDKRB1 and BDKRB2) were associated with anxiety disorders (p < 0.05).

The kallikrein-kinin (KKS) cascade pathway generates the active kinin peptides. Kinin signaling plays important roles in the cardiovascular, renal, respiratory and nervous systems. It elicits vasodilator, inflammatory and pain responses and it exert …