2023年9月8日 · Oncogenic KRAS promoted IRE1α protein stability through extracellular signal-regulated kinase (ERK)-dependent phosphorylation of IRE1α, leading to IRE1α disassociation …

2023年9月27日 · Writing in Science, Lv et al. report that oncogenic KRAS ensures protein quality control in cancer cells by stabilizing the major mediator of the unfolded protein response …

2023年1月9日 · IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing a computational …

2024年4月1日 · In this review, we deliver evolutive and structural insights on IRE1 and further describe how this protein interaction network (interactome) regulates IRE1 signaling abilities or …

KRAS activation diminishes ER stress in KRAS-mutant cells, predominantly via the oncogenic kinase-mediated phosphorylation of IRE1a (Figure 1A). Upon KRAS suppression, a disruption …

Lv et al. discovered a mechanism that rewires the proteostasis network to escape oncogenic KRAS addiction and promote resistance to KRAS inhibitors (KRASi). Inactivation of mutant …

RTK-mediated reactivation of ERK and hyperacti-vation of AKT sustained the unconventional phosphorylation of IRE1 in the KRASi-resistant. tumors, which consequently restored its …

2023年2月1日 · 使用 NSCLC 的KRAS 小鼠模型，发现 癌细胞固有的 IRE1α 促进显着的肿瘤内免疫抑制，从而促进恶性进展。 首先，研究人员开发了一个计算模型，量化剪接的XBP1 mRNA …

2023年9月9日 · 该研究首次报道了蛋白质稳态调控网络重编程的分子机制及其在kras抑制剂耐药性中的重要功能。

2023年11月13日 · In the remaining cells, a subset can reactivate one of the endoplasmic reticulum (ER) stress sensors, specifically the inositol-requiring enzyme 1 alpha (IRE1α) …