2014年6月10日 · Here we show that the K-Ras – JNK axis plays a pivotal role in the maintenance of pancreatic CSCs/CSLCs. In vitro inhibition of JNK, either pharmacological or genetic, caused loss of the self-renewal and tumor-initiating capacity of pancreatic CSLCs.

2023年12月18日 · The JNK pathway responds strongly to cytokines, growth factor deprivation, intracellular stimuli (e.g., DNA damage, cytoskeletal changes, oxidative, and ER stress), and extracellular stressors (e...

2023 年 7 月 19 日，来自斯坦福大学的研究团队在 Nature 发文 KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming ，揭示了 KRAS(G12D) 通过将分化的 AT1 细胞重新编程回 AT2 干细胞，从而生成惰性肿瘤的过程。

2021年7月21日 · 目前，在人类的癌症发生过程中，主要有kras、hras和nras这三类ras蛋白。 突变导致的RAS蛋白永久性激活在所有人类癌症中占据非常高的比例，故针对RAS的抑制剂是治疗癌症的有效药物。

Our results unequivocally demonstrate that impaired JNK signaling sensitizes the pancreas to Kras G12D-induced mPanIN formation, with strong genetic evidence that Kras G12D combined with compound MKK4/MKK7 deficiency is sufficient to produce advanced malignant disease.

2025年2月4日 · In this study, we demonstrate that KRAS mutants confer resistance to platinum in NSCLC. Mechanistically, KRAS mutants mediate platinum resistance in NSCLC cells by activating ERK/JNK signaling, which inhibits AlkB homolog 5 (ALKBH5) N6-methyladenosine (m6A) demethylase activity by regulating posttranslational modifications (PTMs) of ALKBH5.

目前，在人类的癌症发生过程中，主要有 kras 、hras和nras这三类ras蛋白。突变导致的ras蛋白永久性激活在所有人类癌症中占据非常高的比例，故针对ras的抑制剂是治疗癌症的有效药物。

2014年7月15日 · Here we show that the K-Ras - JNK axis plays a pivotal role in the maintenance of pancreatic CSCs/CSLCs. In vitro inhibition of JNK, either pharmacological or genetic, caused loss of the self-renewal and tumor-initiating capacity of pancreatic CSLCs.

为了确定RAC1和CDC42下调与JNK或p38 MAPK激活之间的相互作用，进行了免疫印迹，发现JNK和p38 MAPK激活在RAC1或CDC42敲低后不受影响。此外，用siRac1或sicdc42处理不影响MIA PaCa-2或PANC-1细胞的增殖（图4 F）。

2024年12月11日 · Direct targeting of the KRAS-G12C–mutant protein using covalent inhibitors (G12Ci) acts on human non–small cell lung cancer (NSCLC). However, drug resistance is an emerging concern in this approach...