2024年8月21日 · RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS being the most frequently mutated and MYC the most amplified. The cooperative interplay between RAS and MYC...

2018年11月12日 · Acute KRAS suppression caused rapid proteasome-dependent loss of MYC protein, through both ERK1/2-dependent and -independent mechanisms. Surprisingly, MYC degradation was independent of PI3K-AKT-GSK3β signaling and the E3 ligase FBWX7. We then established and applied a high-throughput screen for MYC protein degradation and …

2024年4月3日 · 在机制上，kras通过上调myc来抑制ifn信号通路直接抑制许多ifn通路基因的表达。 在KRAS突变的肺肿瘤中， MYC的共激活 可通过分泌 CCL9 和 IL-23重塑TME ，导致T细胞、B细胞和NK细胞被排除，免疫抑制M2巨噬细胞浸润。

2017年11月30日 · In a mouse lung model of KRas G12D-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma. We identify epithelial-derived signaling molecules CCL9 and IL …

2023年5月8日 · Mutant KRAS induces MYC gene expression and promotes MYC and ARF6 G4-mRNA translation via increasing eIF4A activity. MYC promotes mitochondrial biogenesis and OXPHOS, whereas ARF6 protects mitochondria from oxidative injury by promoting anterograde trafficking of mitochondria which is linked to the activation of integrin recycling and cell ...

2024年9月27日 · kras 与 myc 的相互作用还激活了腺苷二磷酸核糖化因子 6 (arf6)，赋予细胞氧化保护能力。 最后，致癌 KRAS 和 MYC 提升了长链非编码 RNA HIF1A-As2、转录因子锌指 E-box 结合同源盒 1 (ZEB1) 和锌指蛋白 GLI1 的水平，促进了侵袭和迁移。

Acute KRAS suppression caused rapid proteasome-dependent loss of MYC protein, through both ERK1/2-dependent and -independent mechanisms. Surprisingly, MYC degradation was independent of PI3K-AKT-GSK3β signaling and the E3 ligase FBWX7.

Systematic investigation of non-small cell lung cancer cell lines revealed that KRAS mutation can paradoxically increase the sensitivity of cells to cytotoxic agents. We identify MYC as a key regulator of the cellular stress responses and tumor cell viability as MYC expression was suppressed in drug-sensitive but not resistant cells.

2024年8月21日 · The cooperative interplay between RAS and MYC constitutes a complex and multifaceted phenomenon, profoundly influencing tumor development. Together and individually, these two oncogenes regulate most, if not all, hallmarks of cancer, including cell death escape, replicative immortality, tumor-associated angiogenesis, cell invasion and ...

Historically labeled as “undruggable”, both KRAS and MYC have posed significant challenges in therapeutic targeting due to their complexity. However, recent advancements in direct KRAS-G12Ci and the introduction of the first direct MYC inhibitors into the clinic mark a significant turning point in cancer therapeutics.