2024年12月25日 · KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type and Ichthyosis . Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Signaling by WNT .

Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene. [5] [6] Kremen1 is conserved in chordates including amphioxus [7] and most vertebrate species. [8] The protein is a type I transmembrane receptor of ligands Dickkopf1, [9] Dickkopf2, Dickkopf3, Dickkopf4, EpCAM [10] and Rspondin1.

2021年11月26日 · Our study revealed an interacting host receptome of SARS-CoV-2, and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,...

Kremen-1和Kremen-2（属于 I型跨膜蛋白）又是能够与Dkk蛋白特异性结合的跨膜蛋白——确切地讲是Dkk1和Dkk2，是继Lrp5, 6以后第二组被发现的Dkk受体，并且较前者而言亲和力更高。 …

2018年5月9日 · We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection.

2025年2月8日 · Gene ID: 83999, updated on 8-Feb-2025. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling.

2020年1月7日 · KREMEN1 (KRM1) is the entry receptor for the largest receptor-group of hand-foot-and-mouth disease causing viruses, which includes CV-A10. We report here structures of CV-A10 mature virus alone...

2021年12月13日 · ASGR1- and KREMEN1-specific antibodies blocked S protein binding and entry into cell lines and reduced infection of lung organoids, suggesting a role for these factors in SARS-CoV-2 infection of...

该基因编码高亲和力的 dickkopf 同系物 1 (DKK1) 跨膜受体，该受体在功能上与 DKK1 协同阻断无翼 (Wnt) /β-连环蛋白信号传导。 编码的蛋白质是膜复合物的一个组成部分，它通过脂蛋白受体相关蛋白 6 (LRP6) 调节典型的 Wnt 信号。 它包含细胞外 kringle、WSC 和 CUB 结构域。 该基因的突变导致外胚层发育不良。 该蛋白还被发现是柯萨奇病毒 A10 的功能性受体，可能是 SARS-CoV-2 的替代进入受体。 [RefSeq 提供，2021 年 11 月]

2021年12月15日 · 研究人员将能够介导sars-cov-2入侵的ace2、asgr1和kremen1统称为ask受体，并从细胞系水平、covid-19病人上呼吸道的单细胞测序水平，以及病人组织感染水平，发现生理条件下同时存在依赖和不依赖ace2的两种感染途径，而asgr1和kremen1在后一途径中发挥重要作用；sars-cov-2 ...