The gene is located on the Watson (plus) strand of the short arm of chromosome 12 (12p13.32). The gene itself is 8,348 bases in length and encodes a protein of 495 amino acids (predicted …

2021年7月26日 · Our data implicate K v 1.1 subunits in controlling spontaneous excitatory synaptic activity in BLA pyramidal neurons. In the CeL, K v 1.1 loss enhances intrinsic …

Kv1.1属于电压门控钾通道的Shaker子家族，在中枢神经系统和周围神经系统中充当神经元兴奋性的关键调节剂。KCNA1是唯一与发作性共济失调1型（EA1）相关的基因，这是一种以共济失 …

Loss-of-function mutations in the KCNA1 (Kv1.1) gene cause episodic ataxia type 1 (EA1), a neurological disease characterized by cerebellar dysfunction, ataxic attacks, persistent …

2020年4月22日 · Kv1.1 belongs to the <i>Shaker</i> subfamily of voltage-gated potassium channels and acts as a critical regulator of neuronal excitability in the central and peripheral …

2020年4月22日 · KCNA1 on chromosome 12p13 encodes the Kv1.1 voltage-gated delayed rectifier K + channel, a protein of 496 amino acids belonging to the Shaker family of voltage …

Kv1.1 and Kv1.2 knockout mice both have seizures beginning early in development; however, each express a different seizure type (pathway), although the channels are from the same …

2020年4月24日 · The Shaker-related Kv1 (Kv1.1-Kv1.8) channels display characteristic low threshold voltage activation ranges, well suited to regulate action potential (AP) threshold and …

Voltage-gated Kv1.1 channels encoded by the Kcna1 gene are traditionally regarded as being neural-specific with no known expression or intrinsic functional role in the heart. However, …

Voltage-gated Kv1.1 potassium channel α-subunits are broadly expressed in the nervous system where they act as critical regulators of neuronal excitability. Mutations in the KCNA1 gene, …