近日， 美国国立儿童健康和人类发育研究所 的研究人员在 Nature 子刊 Nature Communications 杂志上发表题为：Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive …

2022年1月8日 · 在 Kv 通道的 12 个亚家族中，Kv4 (Kv4.1–Kv4.3) 通道介导瞬时外向 A 型电流，其特点是在亚阈值膜电位下快速激活、快速失活和从失活状态快速恢复 。 在神经元中，Kv4 位 …

2020年12月1日 · The voltage-gated potassium channel Kv4.2 is a critical regulator of dendritic excitability in the hippocampus and is crucial for dendritic signal integration. Kv4.2 mRNA and …

2020年3月26日 · We show that activity-induced Kv4.2 phosphorylation triggers Pin1 binding to, and isomerization of, Kv4.2 at the pThr 607 -Pro motif, leading to the dissociation of the Kv4.2 …

2021年8月20日 · Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal …

2009年5月14日 · Kv4.2 is the major voltage-gated K + (Kv) channel α subunit responsible for the somatodendritic transient or A-type current I SA that activates at subthreshold membrane …

5 天之前 · Kv4.2 subunits, which mediate transient A-type K+ current, are crucial in regulating neuronal excitability and synaptic responses within the hippocampus. While their contribution …

Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus. The sequence of Kv4.2 contains several …

Shal型钾离子通道 也称为KV4.1、KV4.2和KV4.3（哺乳动物），在大脑和心脏中高度表达，分别调节神经元兴奋性和心脏起搏等多种生理功能。在衰老及其相关疾病的背景下，本文将主要关注 …

Rapidly activating and rapidly inactivating voltage-gated A-type K+ currents, IA, are key determinants of neuronal excitability and several studies suggest a critical role for the Kv4.2 …