2007年2月20日 · Here we show that KYP-dependent H3K9me2 is found at non-CG methylation sites in addition to those rich in CG methylation. Furthermore, we show that the SRA domain of KYP binds directly to methylated DNA, and SRA domains with missense mutations found in loss-of-function kyp mutants have reduced binding to methylated DNA in vitro. These data ...

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2016年2月5日 · This r-KYP 2 O 7 exhibits an open framework constructed by 4- and 6-membered polyhedral rings, which differs a lot from the known ɑ-KYP 2 O 7 and β-KYP 2 O 7. The luminescence properties of r- KYP 2 O 7 have been investigated by doping various rare …

2014年8月7日 · We report on the structure of KYP in complex with methylated DNA, substrate H3 peptide, and cofactor SAH, thereby defining the spatial positioning of the SRA domain relative to the SET domain.

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2007年2月20日 · These data suggest that DNA methylation is required for the recruitment or activity of KYP and suggest a self-reinforcing loop between histone and DNA methylation. Lastly, we found that SRA domains from two Arabidopsis SRA-RING proteins also bind methylated DNA and that the SRA domains from KYP and SRA-RING proteins prefer methylcytosines in ...

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