2018年，Lollobrigida等 首次提出了液体L-PRF的概念，将种植体材料浸润于液体L-PRF中，发现液体L-PRF可在种植体表面形成L-PRF凝胶，使更多的细胞黏附于种植体表面，而L-PRF浸出液虽然能促进种植体表面与纤维蛋白的结合，却无法形成纤维蛋白凝胶。

Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and leukocytes are present in a complex fibrin matrix [1] [2] to accelerate the healing of soft and hard tissue [3] and is used as a tissue-engineering scaffold in oral and maxillofacial surgeries. PRF falls under FDA ...

Platelet-rich fibrin (PRF) represents second generation of platelet concentrates, which has gained increasing awareness in recent years for regenerative procedures. This biologic additive is completely autologous, easy to prepare, has minimal ...

2018年11月5日 · Leukocyte and platelet-rich fibrin (L-PRF) is a 3-D autogenous biomaterial derived via simple and rapid centrifugation of whole blood patient samples, in the absence of anti-coagulants, bovine thrombin, additives or any gelifying agents.

In recent years, leucocyte- and platelet-rich fibrin (L-PRF) has emerged as a highly promising technique with many applications in periodontal therapy. It is being used successfully to repair periodontal bony defects, for ridge preservation, for sinus-floor elevation, and in implant surgery.

2024年5月27日 · Autologous platelet concentrates (APCs) have demonstrated clear benefits across various clinical applications, including alveolar ridge preservation, guided tissue regeneration, guided bone regeneration, sinus floor elevation (both lateral window approach and transcrestal technique), endodontic surgery, the treatment of medication-related osteon...

2020年2月12日 · The hypotheses tested include (i) L-PRF allows the release of growth factors in a sustained manner, (ii) L-PRF increases the SC proliferation and secretion of neurotrophic factors in a ...

Objective: To determine whether leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF+) differ in their in vitro capacity to induce proliferation and migration of periodontal fibroblasts. Background: L-PRF and A-PRF + are autologous materials used in periodontal regenerative surgery. They derive from blood from ...

The new generation of platelet-rich fibrin (PRF), namely advanced PRF (A-PRF), has different biological and mechanical properties compared to those of leukocyte-PRF (L-PRF). This study aimed to compare the effects of L-PRF and A-PRF on the viability and migration of human gingival fibroblasts (HGFs).

The use of leukocyte- and platelet-rich fibrin (L-PRF) to cure skin ulcers is a simple and inexpensive method, widely used in some countries but unknown or neglected in most others. This auto-controlled prospective cohort study explored and quantified accurately for the first time the adjunctive benefits of topical applications of L-PRF in the ...