2020年6月24日 · Mice have 30 or 31 DRG pairs, depending on genetic background [17,18,19]: eight cervical (C1 to C8), 13 thoracic (T1 to T13), five or six lumbar (L1 to L5/L6) and four sacral (S1 to S4). Lumbar DRG are most often studied; however, ganglia at different spinal levels show clear distinctions not only in development, size, cell number and ...

The greatest width of the DRG was 6.5mm bilaterally at L5 (range 3.2-6.5mm). The nerve root take off angle was largest at L5 on the left (range 50.5o-58.8o) and L4 on the right (range 50.5o-57.2o). The center of the DRG was found bilaterally in the medial zone of the foramen of L1-4 and lateral zone at L5.

2025年1月15日 · By directly applying the GABA antagonist to the L5 DRG, we confirm the role of GABAergic modulation in LIFU-induced analgesia through the CGRP-mediated nociceptive pathway. The findings were further supported by results from DRG primary cultures.

2024年3月22日 · The dorsal root ganglion (DRG) serves as a pivotal site for managing chronic pain through dorsal root ganglion stimulation (DRG-S). In recent years, the DRG-S has emerged as an attractive modality in the armamentarium of neuromodulation therapy due to its accessibility and efficacy in alleviating chronic pain refractory to conventional treatments.

2019年7月12日 · Here, we develop a method for imaging DRG at cellular and subcellular resolution over weeks in awake mice. The method involves the installation of an intervertebral fusion mount to reduce spinal...

2023年4月10日 · Introduction: Dorsal root ganglia (DRG) are anatomically well-defined structures that contain all primary sensory neurons and are distension nodules of the dorsal root in the spinal cord near the medial surface of each foramen. Therefore, DRG is considered to be a desirable target for injection to manage chronic pain.

2024年11月1日 · The DRGs lie underneath the laminar bone at the base of the transverse processes. The sciatic nerve sensory axons arise primarily from the L3-L5 DRGs (b), with most of the sciatic contributions projecting into the L3 and L4 DRGs. The location of the lumbar DRGs can be identified by position relative to the iliac crest (yellow) (c).

其潜在的神经元机制仍不明确，但使用 pnp 动物模型（包括 l5 脊髓神经轴突切断术 (l5-sna) 模型）的临床前研究表明，它部分是由背根神经节 (drg) 神经元的兴奋性变化引起的。

In another study, they found that the DRG is positioned more lateral from L1 through L5, with a high percentage of L5 DRG located in the neuroforaminal space (29).

2023年4月15日 · We aimed to explore activation of the Notch signaling pathway in knee-innervating lumbar dorsal root ganglia (DRG) in the course of experimental osteoarthritis (OA) in mice, and its role in knee hyperalgesia. Cultured DRG cells were stimulated with the TLR4 agonist, lipopolysaccharide (LPS).