Nature系列重磅成果发布：大脑运动皮层的细胞图谱！国产fMOST技术助力多篇研究…
2021年10月24日 · 这两组细胞通过与特定标记基因相关的表观基因组峰值进一步区分，Slco2a1代表SCF L5 ET（1）型，Npnt代表SCF L5 ET（2-3）型（图8c）。在Epi-retro-seq，形态学以 …
Spatial transcriptomics reveals the distinct organization of mouse ...
2023年10月16日 · We employed Augur 57 to identify the cell type(s) that are transcriptionally most perturbed by chronic pain, which revealed L5 ET 1 as the most affected subtype followed …
Signature morpho-electric, transcriptomic, and dendritic …
In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5) extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these …
A multimodal cell census and atlas of the mammalian primary …
2021年10月6日 · Here we use the term L5 ET (layer 5 extratelencephalic) to refer to this prominent and distinct subclass of neurons as a standard name that can be accurately used …
Transcriptomics identifies a human L5 neuron corresponding to extratelencephalic projecting neurons in mouse neocortex. Patch-seq recordings from this cell type reveal many conserved …
Local connectivity and synaptic dynamics in mouse and human
ET pyramidal cells were generally more highly connected, receiving more local excitation and inhibition than IT cells. We confirmed a much higher rate of recurrent connections among L5 …
皮质第五层锥体神经元：全麻的潜在靶点 - 健康界
2022年10月9日 · L5兴奋性锥体神经元（pyramidal neurons, PNs）根据输出类型分为三种：长程投射至其他皮质区域的intratelencephalic（IT）神经元；投射至下丘脑等皮质下区域 …
Signature morpho-electric, transcriptomic, and dendritic ... - PubMed
2021年9月15日 · In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5) extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of …
人类第 5 层新皮质锥体神经元的特征形态电、转录组学和树突状特 …
在新皮层中，脑下轴突投射主要起源于第 5 层 （l5） 端脑投射 （et） 神经元。 这些神经元独特的形态电特性主要在啮齿动物中描述，其中逆行示踪剂或转基因系可以标记它们。
Neocortical layer 5 subclasses: From cellular properties to roles in ...
L5 pyramidal neurons are grouped into two subclasses based on their projection targets; while intratelencephalic (IT) neurons project to cortical areas and the striatum, extratelencephalic …