白细胞介素 4（IL-4）是主要由活化的 T 淋巴细胞、肥大细胞、嗜碱性粒细胞产生的一种多效性细胞因子。 1982 年 Howard 发现 T 细胞培养上清中有一种促进 B 细胞增殖的因子，起初命名为 B 细胞生长因子 1，也称为 B 细胞刺激因子 1、 T 细胞生长因子 2。 1986 年基因克隆成功，国际统一命名 IL-4。 人 IL-4cDNA 序列有 153 个氨基酸残基前体蛋白，成熟 IL-4 由 24 个氨基酸残基的信号肽裂解产生，基因定位于第 5 号染色体，与 IL-3、IL-5、IL-13 和 GM-CSF 的基因临近。 在氨 …

2024年7月31日 · Using organoids and mouse models, we show that IL-4 directly acts on a subset of ATIIs to induce the expression of the transcription factor SOX9 and reprograms them toward a progenitor-like state with both airway and alveolar lineage potential.

2025年1月25日 · We investigate IL-4 activation of male C57BL/6 and BALB/c strain specific in vivo tissue-resident macrophages (TRMs) from the peritoneal cavity. C57BL/6 TRMs are more transcriptionally responsive...

碧芯生物推出的Beadstar-mPlex®Human/Mouse Th1/Th2/Th17试剂盒（流式荧光法）可以同时检测这7种细胞因子，相比较于ELISA，整个方法只需要一份样本即可检测多个细胞因子，整个检测过程3个半小时，现在还有75折活动，欲了解更多信息，请访问我们的官方网站： beadstar.cn，或咨询18189751352（微信同号），我们的专业团队将竭诚为您服务。 在做细胞因子检测时，测量IL-2、IL-4、IL-6、IL-10、TNF、IFN-γ以及IL-17A等细胞因子对于评估机体的免疫状态和炎症反 …

白细胞介素-4诱导B细胞抗体类别转换向IgE，上调第二型 主要组织兼容性复合体 的产生。 这一因子是由M·霍华德、W·保罗和E·委特塔（Vitetta）在1982共同发现的。 四年后人类白细胞介素-4的核苷酸序列中被分离，证实它与一小鼠蛋白B细胞刺激因子-1（BCSF-1）类似 [4]。 ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Mouse PubMed Reference:.

Interleukin-4 (IL4) is a secreted immunoregulatory cytokine critically involved in host protection from parasitic helminths [1]. Reasoning that helminths may have evolved mechanisms to antagonize IL4 to maximize their dispersal, we explored mammalian IL4 evolution.

Here, we identify opposing roles of interleukin-4 (IL-4) cytokine signaling in interstitial macrophages and type II alveolar epithelial cells (ATIIs). We show that IL4Ra signaling in macrophages promotes regener-ation of the alveolar epithelium after …

白细胞介素-4 （IL-4） 是一种糖基化的I型细胞因子，分子大小约为20kD，具有三个链内二硫键，采用捆绑式四α螺旋结构。 主要由 活化的T细胞、肥大细胞、嗜酸性粒细胞和 嗜碱性粒细胞 产生。 IL-4对 B细胞、T细胞、肥大细胞、巨噬细胞和造血细胞都有免疫调节作用，对T、B淋巴细胞的发育以及驱动体液免疫反应和抗体产生都是十分重要的。 针对B细胞，IL-4增强B细胞上MHC II类和Fcϵ受体分子的表达，并促进其IgE和IgG1的分泌，增强 B细胞提呈抗原能力，使免疫系统对小 …

2024年3月29日 · 白细胞介素-4受体（IL-4R，又叫CD124；IL4Rα）是一种I型跨膜蛋白，属于白细胞介素家族成员之一。 IL4Rα链cDNA全长3.6 kb，含有一个编码825个氨基酸的开放阅读框架，根据推测其中包括信号序列（25个氨基酸），细胞外区（207个结合域氨基酸），跨膜区（24个氨基酸），细胞内区（569个氨基酸）。 人IL4R存在三种类型：Type I由高特异性亲和力a链（IL-4Ra）和IL-2Rγ链构成；Type II由IL-4Ra链和IL-13Ra链构成；Type III由IL-4Ra链、IL-13Ra …

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop.

IL-4 is critical not only for careful control of immunoglobulin production but also related to inflammation, fibrosis, allergic reactions, and antitumor activity, with actions of IL-4 occurring through two different types of receptors, one of which is also used by IL-13, a closely related cytokine with partially overlapping actions.

Studies of IL-4 have revealed a wealth of information on the diverse roles of this cytokine in homeostatic regulation and disease pathogenesis. Recent data suggest that instead of simple linear regulatory pathways, IL-4 drives regulation that is full of alternatives.

2025年1月1日 · Interleukin-4 (IL-4), which is traditionally associated with inflammation, has emerged as a key player in tissue regeneration. Produced primarily by T-helper 2 (Th2) and other immune cells, IL-4 activates endogenous lymphocytes and promotes M2 macrophage polarization, both of which are crucial for tissue repair.

2024年11月20日 · Physical proximities among REs were coordinately remodeled in three-dimensional space after cell activation, leading to divergent compartmentalization of Il4, Il13 and Il5 with varied...

2023年12月6日 · Our study defines a central role for IL-4 in controlling immunosuppressive myelopoiesis in cancer, identifies a novel combination therapy for immune checkpoint blockade in humans, and highlights...

2021年9月7日 · IL-4 is critical not only for careful control of immunoglobulin production but also related to inflammation, fibrosis, allergic reactions, and antitumor activity, with actions of IL-4 occurring through two different types of receptors, one of which is also used by IL-13, a closely related cytokine with partially overlapping actions.

It is a signature cytokine of type 2 immune response but also has a nonimmune function. Its expression is tightly regulated at several levels, including signaling pathways, transcription factors, epigenetic modifications, microRNA, and long noncoding RNA.

2022年11月8日 · Our findings establish that IL-4-induced epigenetic reprogramming is responsible for the development of inflammatory hyperresponsiveness to TLR activation and contributes to lung pathologies. Keywords: EGR2; IL-4; LPS; STAT6; Th2-type airway inflammation; epigenetic reprogramming; inflammation; macrophage; synergistic gene activation.

2024年6月3日 · IL-9 has diverse sources that include CD4 + T cells, CD8 + T cells, innate lymphoid cells (ILCs), mast cells, and basophils 1. While the sources and functions of IL-9 are tissue- and...