2022年2月1日 · LAT1 regulates cell proliferation upstream of mTORC1. In addition to inhibiting mTORC1, LAT1 inhibitors activate the GAAC pathway to suppress translation initiation. LAT1 is induced to be expressed in response to lysoPC and angiogenic growth factors in vascular endothelial cells, contributing to arteriosclerosis and tumor angiogenesis ...

5 天之前 · Heteromeric amino acid transporters (HATs), including y + LAT1-4F2hc complex, are responsible for transporting amino acids across membranes, and mutations in y + LAT1 cause lysinuric protein intolerance (LPI), a hereditary disorder characterized by defective cationic amino acid transport. The relationship between LPI and specific mutations in y …

2024年10月19日 · Glioblastoma, a fatal brain cancer with limited treatments and poor prognosis, could benefit from targeting the L-type amino acid transporter I (LAT1). LAT1 is essential for cancer cells to acquire necessary amino acids. Tetrahydrocurcumin (THC), a key curcumin derivative, shows potential for glioblastoma treatment.

2016年10月15日 · Large neutral amino acid transporter 1 (LAT1) is a solute carrier protein located primarily in the blood–brain barrier (BBB) that offers the potential to deliver drugs to the brain. It is also up-regulated in cancer cells, as part of a tumor’s increased metabolic demands. Previously, amino acid prodrugs have been shown to be transported by ...

2020年3月30日 · We characterized the role of LAT1 by determining whether the inhibition of LAT1 activity reduces the penetration of LAAM TC-CQDs in an in vitro BBB model as well as in vivo in tumour bearing...

2015年4月13日 · L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop a LAT1-mediated chemothe...

5 天之前 · Heteromeric amino acid transporters (HATs), including y+LAT1- 4F2hc complex, are responsible for transporting amino acids across membranes, and mutations in y+LAT1 cause lysinuric protein intolerance (LPI), a hereditary disorder characterized by …

2017年3月2日 · In this review, we present current information on amino-acid transporters, such as LAT1 (l -leucine transporter), ASCT2 (l -glutamine transporter) and GAT-1 (γ -aminobutyric acid transporter-1),...

2024年9月1日 · The paracellular AA flux except for Ser, Thr, Tyr, Ala, and Gly was enhanced by CLDN1 silencing. These results suggest that CLDN1 forms a paracellular barrier to some AAs, leading to the elevation of LAT1/3 expression in spheroids.

2020年9月22日 · Two sodium independent transport systems, LAT1 or L, and y +, mediate the facilitated exchange of large neutral AAs (both systems) and basic AAs (y +) in both luminal and abluminal membranes of ECs. They play a key role in delivering dietary essential neutral and basic AAs that cannot be synthesized within the brain ( Stoll et al., 1993 ...