The Regulation and Function of the L-Type Amino Acid …
Increasing the uptake of leucine into cells is the most effective way that LAT1 promotes the activity of Mechanistic Target of Rapamycin Kinase Complex 1 (mTORC1). LAT1 not only …
Amino acid transporter LAT1 (SLC7A5) as a molecular target for …
2022年2月1日 · The inhibition of LAT1 suppresses protein synthesis by downregulating the mTORC1 signaling pathway and mobilizing the general amino acid control (GAAC) pathway in …
Expression of L-type amino acid transporter 1 as a molecular
2020年1月28日 · JPH203 inhibited phosphorylation of MAPK / Erk, AKT, p70S6K and 4EBP-1. Multivariate analysis revealed that high LAT1 expression was found as an independent …
L-Type Amino Acid Transporter 1 Regulates Cancer Stemness and …
2021年10月11日 · The l-type amino acid transporter 1 (LAT1) is a membranous transporter that transports neutral amino acids for cells and is dysregulated in various types of cancer. Here, …
The L-type amino acid transporter LAT1 inhibits …
2019年7月7日 · The LAT1-mTORC1 axis (red dashed square) inhibits the activation of Akt, thus preventing GSK3β from stimulating the translocation of NFATc1 from the nucleus to the …
氨基酸转运蛋白 LAT1 (SLC7A5) 作为癌症诊断和治疗 ... - X-MOL
LAT1 对癌细胞生长至关重要，因为 LAT1 的药理学抑制和敲低/敲除可抑制癌细胞的增殖和异种移植肿瘤的生长。 LAT1 的抑制通过下调 mTORC1 信号通路和调动癌细胞中的一般氨基酸控制 …
L-Type Amino Acid Transporter 1 (LAT1) Promotes PMA-Induced …
2023年10月23日 · Taken together, lysosomal LAT1 recruits and activates the mTORC2 complex and downstream Akt for PMA-mediated cell migration. These results provide insights into the …
Amino acid transporter LAT1 (SLC7A5) as a molecular target for …
The inhibition of LAT1 suppresses protein synthesis by downregulating the mTORC1 signaling pathway and mobilizing the general amino acid control (GAAC) pathway in cancer cells. LAT1 …
L-type amino-acid transporter 1 (LAT1): a therapeutic target
2014年12月8日 · Our results show that overexpressed LAT1 on T-ALL/T-LL cancer cells reflects a cancer addiction towards increased nutrients uptake for mTORC1 and Akt activation and …
重大突破！LAT1 抗癌药物识别及氨基酸转运的结构基础全新解析
2025年2月15日 · 该研究对于深入理解氨基酸转运蛋白 LAT1（L-type amino acid transporter 1，L 型氨基酸转运蛋白 1）在癌症治疗、免疫反应以及药物递送等方面的作用机制具有重要意义， …