Structure of the human LAT1–4F2hc heteromeric amino acid …
2019年3月13日 · Here we report the cryo-electron microscopy structures of human LAT1–4F2hc alone and in complex with the inhibitor 2-amino-2-norbornanecarboxylic acid at resolutions of …
l-Type amino acid transporter 1-targeting nanoparticles for …
2024年12月10日 · l -Type amino acid transporter 1 (LAT1)-specific ligands and polyion complexes are used as brain-specific targets to deliver RNA-based drugs across the blood-brain barrier. …
Crossing the blood–brain barrier: emerging therapeutic strategies …
2025年1月22日 · Novel strategies have been developed to circumvent the blood–brain barrier, including CSF delivery, intracranial delivery, ultrasound-based methods, membrane …
Heteromeric amino acid transporters in brain. LAT1/CD98hc, …
Here, we summarize (i) structural insights that help to explain how LAT1 and 4F2hc assemble to transport amino acids across membranes, (ii) the role of LAT1‐4F2hc in key metabolic …
L-Type amino acid transporter 1 as a target for drug delivery
Due to the significant up-regulation of LAT1 expression in several human tumors, LAT1 has been an attractive transporter for targeted delivery of amino acid-derived anticancer drugs and …
Transport of Amino Acids Across the Blood-Brain Barrier - Frontiers
2020年9月22日 · The spectrum of substrates is similar to that of system LAT1 that transports essential NAAs with a concentration gradient. It seems that Na + -LNAA in the abluminal …
The Multifaceted Role of L-Type Amino Acid Transporter 1 at
2024年9月26日 · L-type amino acid transporter 1 (LAT1) is integral to the transport of large neutral amino acids across the blood-brain barrier (BBB), playing a crucial role in brain …
Frontiers | Blood-Brain Barrier and Delivery of Protein and Gene ...
2020年1月9日 · CSF injection of drug is the most widely practiced approach to brain delivery that bypasses the BBB. However, drug injection into the CSF results in limited drug penetration to …
周强组解析首个人源氨基酸转运体LAT1–4F2hc复合体结构_光谱网
2 天之前 · 2019年3月14日，西湖大学生物学研究所周强研究员团队在Nature发表了题为Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex的论文（第一单位为清 …
L-type amino acid transporter 1 as a target for inflammatory disease ...
2022年1月1日 · In this review, we aimed to introduce the function of amino acids and their transporters in immune cells, with emphasis on L-type amino acid transporter 1 (LAT1), a …