L-type amino-acid transporter 1 (LAT1): a therapeutic target
2014年12月8日 · The current study demonstrates that inhibiting LAT1/SLC7A5, an essential amino-acid (EAA) transporter, alters metabolism and survival of ALL/T-LL cellular models such …
氨基酸转运蛋白 LAT1 (SLC7A5) 作为癌症诊断和治疗 ... - X-MOL
lat1 对癌细胞生长至关重要，因为 lat1 的药理学抑制和敲低/敲除可抑制癌细胞的增殖和异种移植肿瘤的生长。 LAT1 的抑制通过下调 mTORC1 信号通路和调动癌细胞中的一般氨基酸控制 …
“脑癌”潜力靶点LAT1，药物设计思路清晰 - 网易
2021年9月30日 · LAT（L-type amino transporters），即L型氨基酸转运体，主要功能为中性氨基酸包括必须氨基酸的转运，亚型按照时间发现顺序依次为LAT1、LAT2、LAT3、LAT4，其 …
LAT1 Is a Critical Transporter of Essential Amino Acids for Immune ...
2013年10月15日 · In this study, we show that L-type amino acid transporter 1 (LAT1) is a major transporter for essential amino acids into activated human T cells. CD3/CD28 stimulation in …
Characterisation of L-Type Amino Acid Transporter 1 (LAT1) …
2017年12月26日 · LAT1/SLC7A5 is a transmembrane amino-acid transporter, which imports leucine and other BCAAs into cells in exchange for glutamine. This places LAT1 as a central …
LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes …
2015年5月22日 · We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or …
重大突破！LAT1 抗癌药物识别及氨基酸转运的结构基础全新解析
2025年2月15日 · 德国马克斯?普朗克生物物理研究所（Department of Structural Biology, Max Planck Institute of Biophysics）的 Yongchan Lee 等人在《Nature Communications》期刊上发 …
The L-type amino acid transporter LAT1 inhibits …
2019年7月7日 · Amino acid substrates of LAT1 are suggested to have a beneficial impact on bone health directly and indirectly. For example, EAA supplements that include Leu and Ile …
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma …
LAT1 was pharmacologically blocked by JPH203 in human ATC and papillary thyroid cancer (PTC) cell lines. The effects on proliferation and mTORC1 activity were addressed in vitro. A …
氨基酸转运载体LAT1研究进展-【维普期刊官网】- 中文期刊服务平台
L-type amino acid transporter-1 （LAT1） is a member of the sodium-independent amino acid transport system L and transports large branched-chain and aromatic neutral amino acids. …