Coupling liquid chromatography (LC) with high-resolution NMR (LC-NMR) aims to simplify the NMR analysis of mixtures by detecting successively the analytes in the course of the elution [72].

液相核磁共振连用,这种新近发展起来的前沿分析技术,由于它比其他技术能提供更充分的结构信息,从而在现代新药的发现平台中居于非常重要的地位.本文综述了液相核磁共振连用技术(lc-nmr)的历史发展,工作原理.探讨了影响lc-nmr工作的nmr灵敏度,溶剂峰的抑制,nmr ...

2021年1月6日 · Liquid chromatography (LC)–nuclear magnetic resonance (NMR) combines the advantage of the outstanding separation power of liquid chromatography (LC) and the superior structural elucidating capability of nuclear magnetic resonance (NMR).

applications of hyphenated NMR as LC-NMR and LC-MS-NMR in industry and academia, such as to natural products, degradation products, impurity characterization, drug metabolism, food analysis, drug discovery, polymers,

The on-line coupling of high-performance liquid chromatography (HPLC) principles to high-resolution NMR spectrometers offers a powerful tool for analyzing and characterizing complex chemical mixtures without the need of chemical separation. LC-NMR

2014年2月14日 · Combined liquid chromatography/nuclear magnetic resonance spectroscopy (LC/NMR) was proposed over 20 years ago, but did not capture the imagination of researchers/developers due to its inherently poor sensitivity. Relatively recent design improvements have improved sensitivity and the technique is now established (References 6,7).

2021年8月25日 · The potential of on-line trace enrichment combined with column liquid chromatography–nuclear magnetic resonance detection (LC–NMR) is demonstrated for the identification of hop bitter acids in...

LC-NMR is very suitable for the detection of complex metabolites in biological samples and the identification of potential markers. LC-NMR can study metabolites at the molecular level, and sequential experiments can identify multiple metabolites at the same time.

2003年7月15日 · Nuclear magnetic resonance spectroscopy (NMR) is arguably the most versatile analytical platform for complex mixture analysis. Specifically, interfacing liquid chromatography with parallel NMR and mass spectrometry (LC–NMR–MS) gives comprehensive structural data on metabolites of novel drugs in development.

LC-NMR, as the name implies, is a directly combined system of HPLC and NMR. Its main features are high sensitivity and reduced separation steps, which make it a powerful tool for structural analysis of trace components (impurities, degradation products, metabolites, etc.) and unstable substances that are easily damaged by separation and ...