Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. [5] LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes. [6]

2024年12月25日 · MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha) is a Protein Coding gene. Diseases associated with MAP1LC3A include Skin Amelanotic Melanoma and Alzheimer Disease 13. Among its related pathways are Selective autophagy and Mitophagy.

Microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein with a molecular mass of approximately 17 kDa that is distributed ubiquitously in mammalian tissues and cultured cells. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organ …

LC3蛋白（也称为 Microtubule-associated protein 1 light chain 3）是一种与细胞自噬相关的蛋白质，在细胞自噬的过程中发挥重要的作用。 通过检测LC3蛋白的表达水平和形态变化，可以研究细胞自噬的活性和调控机制。 许多疾病，如癌症、神经退行性疾病和肝脏疾病等，与细胞自噬的异常相关，因此研究LC3蛋白及其参与的细胞自噬机制对理解这些疾病的发生和治疗具有重要意义。 LC3蛋白是一个亚家族，包含几个亚型或Isoform，包括LC3A、LC3B和LC3C。 这些亚型在结 …

2025年2月16日 · Gene and protein expression of mTOR and LC3 in hepatocellular carcinoma, colorectal liver metastasis and ""normal"" liver tissues. A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.

2025年2月1日 · LC3B, a member of the LC3/GABARAP family, is a ubiquitin-like protein that orchestrates autophagy alongside phosphatidylethanolamine (PE) through a series of E1-E2-E3 conjugation reactions. This process suggests an intersection with the ubiquitin-proteasome system, where LC3B levels are modulated through ubiquitination and subsequent ...

2025年2月8日 · Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging. STING directly activates autophagy to tune the innate immune response. TP53INP2 interacted directly with ATG7 to form a LC3B-TP53INP2-ATG7 complex in the cytoplasm.

2025年2月4日 · Nature Communications - LC3 is required for canonical and non-canonical autophagy. Here, the authors uncover LAPTIN, a function of LC3 triggered by integrin LFA1 outside-in signaling, which...

2025年2月16日 · LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy. Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients. Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma.

2020年10月18日 · The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key marker for autophagosomes and as a proxy for autophagic flux. Three paralogues of the LC3 gene exist in humans: LC3A, LC3B and LC3C.