With more than 3 million longitudinally followed research participants and 70 000 incident lung cancer cases included in the centralized database, the LC3 provides an unprecedented …

More than 3 million participants and more than 67 000 lung cancer cases occurring among never, former, and current smokers. Zoom image.

2025年2月1日 · LC3B drives autophagy via interaction with autophagy-related proteins, autophagosome-lysosome fusion, and transcriptional cofactor activity. LC3B modulates …

2023年6月1日 · We defined imminent lung cancer as a clinical lung cancer diagnosis within three years of blood draw and identified 731 lung cancer cases and 731 smoking-matched controls …

Keywords: Autophagy; LC3A; SOX2; cancer cell plasticity; lung cancer; mitochondria dynamics. This work was supported by National Tsing Hua University and Ministry of Science and …

LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have a similar biological role in …

2023年6月20日 · In CHI3L1-overexpressing lung cancer cells, the expression of LC3, an autophagosome marker, and the accumulation of LC3 puncta increased. In contrast, CHI3L1 …

3 天之前 · Clinical lung cancer samples show a positive correlation between RBM38c expression and LC3 expression, and this correlation is linked to chemotherapy resistance.

Both mRNA and protein levels of Beclin-1 and LC3-II were significantly decreased in lung cancer tissues which suggested that autophagy may be involved in the pathogenesis of lung cancer.

2022年5月6日 · Protein light chain 3 (LC3) and p62/SQSTM1 (p62) are associated with autophagosomal membranes that engulf cytoplasmic content for subsequent degradation. We …