LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.

2024年12月25日 · LHX3 (LIM Homeobox 3) is a Protein Coding gene. Diseases associated with LHX3 include Pituitary Hormone Deficiency, Combined, 3 and Non-Acquired Combined Pituitary Hormone Deficiency-Sensorineural Hearing Loss-Spine Abnormalities Syndrome. Among its related pathways are Nervous system development and Beta-2 …

LHX3 is a transcription factor that belongs to the LIM-type homeodomain protein family. It is involved in cell specification and proliferation during development and is expressed in the pituitary, spinal cord, and medulla. Mutations in LHX3 can lead to deficits in pituitary hormones and abnormal pituitary morphology.

2024年6月17日 · LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma. Lin X, et al. Oncol Rep, 2017 Sep. PMID 28731174, Free PMC Article. Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma. Liu H, et al. Mol Cell Biochem, 2015 Jan. PMID 25399296.

2024年3月5日 · LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma. Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma. A recessive mutation resulting in a disabling amino acid substitution (T194R) in the LHX3 homeodomain causes combined pituitary hormone deficiency.

LHX3, a LIM-homeodomain transcription factor, is broadly expressed in the developing pituitary, spinal cord, medulla, retina and inner ear, and plays essential roles during embryonic development. Mice with homozygous Lhx3 null mutation exhibit failure in the formation of pituitary gland and die peri …

The Lhx3 gene encodes two isoforms, LHX3a and LHX3b, that differ in their amino-terminal sequences. A novel LHX3 protein (M2-LHX3) is identified and it is determined that this molecule is generated by an internal translation initiation codon.

LHX3 is a member of the LIM-homeodomain (LIM-HD) subfamily of transcription factor proteins that are characterized by a DNA-binding homeodomain in the middle of the protein and two amino terminal LIM domains (cysteine-rich structures important for protein–protein interactions) [2].

该基因编码携带 LIM 结构域的一大类蛋白质的成员，LIM 结构域是一种独特的富含半胱氨酸的锌结合结构域。 编码的蛋白质是垂体发育和运动神经元规范所需的转录因子。 该基因的突变导致垂体激素联合缺乏症 3。 可变剪接导致编码不同亚型的多个转录变体。 [RefSeq 提供，2015 年 12 月] This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain.

LHX3 is involved in the generation of 2 adjacent but distinct cell types for locomotion, motor neurons and V2 interneurons. Using in vivo function and protein interaction assays, Thaler et al. (2002) found that LHX3 binds directly to the LIM cofactor NLI (603451) to …