2020年6月26日 · Experimental and field-theoretic simulation results are consistent with PEG driving LLPS by dehydration of polymers, and show that PEG exerts its effect without partitioning into the dense...

2023年10月4日 · Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon underlying the sequestration of macromolecules (such as proteins and nucleic...

LLPS的发生，高度依赖溶液中生物大分子（比如：蛋白，DNA以及RNA等）的浓度、物理化学性质，以及溶液所处的环境，比如：温度、pH、盐离子浓度、盐离子类型以及溶液中存在其它的生物大分子。

2021年5月27日 · LLPS is a thermodynamically transient, nonequilibrium process leading to phase segregation (nonassociative or segregative phase separation) or the formation of coacervates...

2021年7月8日 · An LLPS system from the gel–sol transition of protein (gelatin solution) in a macromolecular crowding agent (PEG solution). a) Schematics and microscopy images of the formation of the LLPS system from the gel–sol transition of physically crosslinked protein microrods in PEG solution at 37 °C (i).

液-液相分离（Liquid-Liquid Phase Separation, LLPS）是指在细胞内某些生物大分子（如蛋白质和RNA）通过相互作用，形成具有不同组分和性质的相分离液滴 [1]。 这些液滴类似于油滴在水中的分离状态，形成了细胞内的…

2021年7月14日 · Here, to the best of our knowledge, we report for the first time LLPS in concentrated aqueous solutions of PEG-based methacrylate homopolymers and their mixtures with Pluronic® F127, a commercially available thermoresponsive polymer, used as a thermogelling, foaming and de-foaming agent, injectable gel, and 3-D printable material. 25 - …

Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon underlying the sequestration of macromolecules (such as proteins and...

Liquid–liquid phase separation (LLPS) can be used as a direct tool for probing both protein–protein and protein–PEG inter-actions. It has been shown that the position of the liquid–liquid boundaries provides insight about the nature and magnitude of the protein–protein interactions (17–20).

2023年12月1日 · This review offers a concise overview of LLPS in soft matter, emphasizing its relevance in soft material engineering. We delve into fundamental mechanisms, focusing on biological systems, and explore the implications of LLPS, spanning organelles, substance exchange, molecular diffusion, and disease associations.