2023年12月22日 · 摘要： 目的:探究二肽基肽酶-4抑制剂西格列汀(SIT)对脂多糖(LPS)诱导急性肺损伤(ALI)的改善作用及具体机制.方法:选取6～8周龄雄性C57BL/6小鼠,随机分为对照组、SIT …

脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的主要成分之一，由类脂A、核心多糖和O-抗原三部分组成，其中O-抗原决定了LPS的血清型，具有重要的生物学功能和作用机制。

2018年5月15日 · The results confirmed that the solubility of Sit derivatives in oil was increased; Sit derivatives did not display cytotoxic effects; and Sit-N treatment showed the strongest hepatoprotective effect against acute liver injury induced by LPS/GalN and suppression characteristics against death.

2018年7月18日 · Intratracheal administration of the selective SIRT1 activator SRT1720 (6.25 mg/kg) significantly attenuated LPS-induced lung injury, lung hyper-permeability and increased TJs expression, whereas...

2023年3月17日 · Overexpression of SIRT6 can alleviate lipopolysaccharide (LPS)‐induced injury of vascular endothelial cells. 7 A study has shown that SIRT6 has a protective effect on radiation‐induced lung injury. 8 In addition, a number of studies have reported that SIRT1 has a protective effect on various types of lung injury, LPS‐induced lung injury is also ...

2020年3月6日 · These findings suggest that SIRT1 is a latent therapeutic target for mitigating LPS-induced inflammation via the TLR4-NFκB-ROS signaling axis.

In this study, 4 kinds of new Sit derivatives were obtained by the esterification reaction. Further, the hepatoprotective effects of Sit and its derivatives were investigated against acute liver injury induced by lipopolysaccharide/ d-galactosamine (LPS/GalN) in mice and its mechanism was illustrated by western blot analysis and real-time PCR ...

社会互动试验 （SIT, Social Interaction Test）：实验者将两只动物放在一起，观察它们的社会互动行为，如互相嗅闻、跟随和攀爬等。抑郁动物往往在社会互动中表现出消极和退缩的行为。

Nrf2 knockout (Nrf2−/−) and wild-type (WT) mice were pre-treated with SIT (100mg/kg), followed by caerulein and lipopolysaccharide (LPS) administration to induce pancreatic and lung injury. BEAS-2B cells were transfected with siRNA-Nrf2 and treated with LPS, and the changes in inflammation, reactive oxygen species (ROS) levels, and ...

脂多糖 （Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的重要成分，对细菌的生存和致病性具有重要影响。LPS位于细菌外膜的外层，在无荚膜菌株中直接暴露在细胞表面。