
Tetramethylpyrazine ameliorates LPS-induced acute lung injury
2024年8月28日 · The findings indicated that the overexpression of miR-369-3p resulted in enhanced lung function, reduced pulmonary edema, inflammation, and permeability in LPS-induced ALI mice, while the ...
miR-369-3p modulates inducible nitric oxide synthase and is
2020年9月29日 · We demonstrated that the ectopic induction of miR-369-3p markedly reduced iNOS mRNA and protein as well as NO production. Moreover, we found that the upregulation of miR-369-3p decreased the...
369‑3p was administered one week prior to LPS‑induced in order to assess its potential ecacy in ameliorating ALI in mice. The ndings indicated that the overexpression of miR ‑369‑3p ...
Tetramethylpyrazine ameliorates LPS-induced acute lung injury via …
2024年8月28日 · The adenovirus carrying miR-369-3p was administered one week prior to LPS-induced in order to assess its potential efficacy in ameliorating ALI in mice. The findings indicated that the overexpression of miR-369-3p resulted in enhanced lung function, reduced pulmonary edema, inflammation, and permeability in LPS-induced ALI mice, while the ...
Tetramethylpyrazine ameliorates LPS-induced acute lung injury via …
Our findings indicate that up-regulation of miR-369-3p can ameliorate LPS-induced ALI by enhancing lung function, reducing pulmonary edema, decreasing pulmonary vascular permeability, and alleviating pulmonary inflammation.
miR-369-3p modulates inducible nitric oxide synthase and is …
2020年9月29日 · miR-369-3p is a negative regulator in LPS-induced inflammatory response in BMDCs. miR-369-3p upregulation in LPS-stimulated BMDCs after mimic transfection led to a significant decrease of TNFα (A), IL-6 (B), IL-12 (C), IL-1α (D), IL-1β (E) and increase of IL-10 (F) and IL-1RA (G) production in response to LPS. The secretion of cytokines was ...
A Novel Mechanism of Immunoproteasome Regulation via miR-369 …
2022年11月9日 · In the present study, we identified PSMB9 as a putative target of miR-369-3p. In our previous works, we demonstrated that miR-369-3p reduced the LPS-induced inflammatory response, and regulated the expression levels of NOS2, decreasing the production of pro-inflammatory agents in dendritic cells [30,31]. In this study, we found that the levels ...
Tetramethylpyrazine ameliorates LPS-induced acute lung injury via …
2024年8月28日 · The findings indicated that the overexpression of miR-369-3p resulted in enhanced lung function, reduced pulmonary edema, inflammation, and permeability in LPS-induced ALI mice, while the suppression of miR-369-3p exacerbated the damage in these mice.
Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal ...
We demonstrated that in inflammatory conditions, miR-369-3p was able to reduce the expression of PDE4B, triggering an intracellular increase in cAMP. As a result, we found a reduction in pro-inflammatory mediator release and an increase in anti-inflammatory mediator production.
Quercetin‐Induced miR‐369‐3p Suppresses ... - Wiley Online Library
2019年7月23日 · It is demonstrated that the loss of function of miR‐369‐3p in LPS‐stimulated DCs during quercetin exposure led to an increase of CCAAT/enhancer binding protein β (C/EBP‐β) mRNA and protein and its downstream targets tumor …
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