2015年11月25日 · The BBB is relatively resistant to LPS-induced disruption with some brain regions more vulnerable than others. LPS-induced disruption appears is to be dependent on COX but not on oxidative stress. Based on in vivo and in vitro measures of neuroinflammation, it appears that astrocytes, microglia/macr …

2024年4月17日 · Single-cell RNA-sequencing analysis reveals that brain endothelial cells (bECs), which express high levels of GSDMD, have a prominent response to circulating LPS. LPS acting on bECs primes...

2015年11月25日 · Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain. We used lipopolysaccharide (LPS) to induce inflammation and BBB disruption in mice.

BB inhibits LPS-induced TLR4 mRNA expression, NF-κB activation and inflammatory cytokine release through the PI3K/Akt pathway. The results of experiment 4 demonstrated that the PI3K/Akt inhibitor LY294002 abolished the inhibition of …

2024年4月18日 · 血脑屏障（Blood–Brain Barrier，BBB）是大脑实质与外周循环系统间的一道保护性天然屏障，由大脑内皮细胞（bEC）与周细胞、平滑肌细胞、星形胶质细胞、小胶质细胞和巨噬细胞共同组成。 血脑屏障允许特定的营养物质从外周循环转运到中枢神经系统（CNS），而阻断不必要或有害物质的进入。 病理性因子或全身性炎症对血脑屏障的破坏，可导致或加剧各种中枢神经系统病变，包括阿尔茨海默病（AD）、渐冻症（ALS）、亨廷顿症（HD）和多发性硬 …

2021年11月4日 · Lipopolysaccharide (LPS), the cell wall component of Gram-negative bacteria, can damage the barrier function of BBB and further promote the occurrence and development of sepsis-associated encephalopathy (SAE).

脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的主要成分之一，由类脂A、核心多糖和O-抗原三部分组成，其中O-抗原决定了LPS的血清型，具有重要的生物学功能和作用机制。

2024年4月18日 · 已经有研究发现，革兰氏阴性细菌的重要促炎因子脂多糖（lps），在感染期间或者单独注射的情况下，会引起血脑屏障受损。不过，lps导致血脑屏障 ...

2024年4月18日 · LPS在细胞膜表面被特定的模式识别受体TLR4识别后，能够激活一系列下游的转录信号通路，以抵抗革兰氏阴性菌感染。此外，进入细胞内部的LPS还能被胞内受体caspase4/5/11所识别，进而触发GSDMD依赖的细胞焦亡信号通路。

How peripheral LPS induces its effects on brain is not clear, but one mechanism is that LPS crosses the blood-brain barrier (BBB). Alternatively, LPS acts outside the BBB by stimulating afferent nerves, acting at circumventricular organs, and altering BBB permeabilities and functions.